Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment

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• dc.contributor.author Martínez-Álvaro, Marina
• dc.contributor.author Zubiri-Gaitán, Agostina
• dc.contributor.author Hernández, Pilar
• dc.contributor.author Greenacre, Michael
• dc.contributor.author Ferrer, Alberto
• dc.contributor.author Blasco, Agustín
• dc.date.accessioned 2023-06-15T06:02:42Z
• dc.date.available 2023-06-15T06:02:42Z
• dc.date.issued 2021
• dc.description.abstract Our study provides an exhaustive comparison of the microbiome core functionalities (captured by 3,936 microbial gene abundances) between hosts with divergent genotypes for intramuscular lipid deposition. After 10 generations of divergent selection for intramuscular fat in rabbits and 4.14 phenotypic standard deviations (SD) of selection response, we applied a combination of compositional and multivariate statistical techniques to identify 122 cecum microbial genes with differential abundances between the lines (ranging from −0.75 to +0.73 SD). This work elucidates that microbial biosynthesis lipopolysaccharides, peptidoglycans, lipoproteins, mucin components, and NADH reductases, amongst others, are influenced by the host genetic determination for lipid accretion in muscle. We also differentiated between host-genetically influenced microbial mechanisms regulating lipid deposition in body or intramuscular reservoirs, with only 28 out of 122 MGs commonly contributing to both. Importantly, the results of this study are of relevant interest for the efficient development of strategies fighting obesity.
• dc.format.mimetype application/pdf
• dc.identifier.citation Martínez-Álvaro M, Zubiri-Gaitán A, Hernández P, Greenacre M, Ferrer A, Blasco A. Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment. Commun Biol. 2021;4:1246. DOI: 10.1038/s42003-021-02784-w
• dc.identifier.doi http://dx.doi.org/10.1038/s42003-021-02784-w
• dc.identifier.issn 2399-3642
• dc.identifier.uri http://hdl.handle.net/10230/57179
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Communications Biology. 2021;4:1246.
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Genetic association study
• dc.subject.keyword Genetics
• dc.title Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion