Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebrates
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- dc.contributor.author Mohd-Padil, Hirzahidaca
- dc.contributor.author Mohd-Adnan, Aduraca
- dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
- dc.date.accessioned 2018-06-07T07:51:57Z
- dc.date.available 2018-06-07T07:51:57Z
- dc.date.issued 2013
- dc.description.abstract Transferrin is a protein super-family involved in iron transport, a central process in cellular homeostasis. Throughout the evolution of vertebrates, transferrin members have diversified into distinct subfamilies including serotransferrin, ovotransferrin, lactoferrin, melanotransferrin, the inhibitor of carbonic anhydrase, pacifastin, and the major yolk protein in sea urchin. Previous phylogenetic analyses have established the branching order of the diverse transferrin subfamilies but were mostly focused on the transferrin repertoire present in mammals. Here, we conduct a comprehensive phylogenetic analysis of transferrin protein sequences in sequenced vertebrates, placing a special focus on the less-studied nonmammalian vertebrates. Our analyses uncover a novel transferrin clade present across fish, sauropsid, and amphibian genomes but strikingly absent from mammals. Our reconstructed scenario implies that this novel class emerged through a duplication event at the vertebrate ancestor, and that it was subsequently lost in the lineage leading to mammals. We detect footprints of accelerated evolution following the duplication event, which suggest positive selection and early functional divergence of this novel clade. Interestingly, the loss of this novel class of transferrin in mammals coincided with the divergence by duplication of lactoferrin and serotransferrin in this lineage. Altogether, our results provide novel insights on the evolution of iron-binding proteins in the various vertebrate groups.
- dc.description.sponsorship This work was supported by grants from the Malaysian Ministry of Science, Technology and Innovation (07-05-MGI-GMB009), the Spanish Ministry of Science and Innovation (BFU2009-09168), and Universiti Kebangsaan Malaysia (UKM-DLP-2011-027)
- dc.format.mimetype application/pdf
- dc.identifier.citation Mohd-Padil H, Mohd-Adnan A, Gabaldón T. Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebrates. Mol Biol Evol. 2013;30(4):894-905. DOI: 10.1093/molbev/mss325
- dc.identifier.doi http://dx.doi.org/10.1093/molbev/mss325
- dc.identifier.issn 0737-4038
- dc.identifier.uri http://hdl.handle.net/10230/34844
- dc.language.iso eng
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Molecular Biology and Evolution. 2013;30(4):894-905
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-09168
- dc.rights © 2013 Hirzahida Mohd-Padil, Adura Mohd-Adnan, Toni Gabaldón. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.other Filogènia
- dc.subject.other Transferrina
- dc.subject.other Vertebrats
- dc.title Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebratesca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion