Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases

Garin Boronat, Olatz, 1979-; Ayuso Mateos, José Luis; Almansa, Josué; Nieto, Marta; Chatterji, Somnath; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi; Cieza, Alarcos; Svetskova, Olga; Burger, Helena; Racca, Vittorio; Francescutti, Carlo; Vieta, Eduard; Kostanjsek, Nenad; Raggi, Alberto; Leonardi, Matilde; Ferrer Forés, Maria Montserrat; MHADIE consortium

Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases

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dc.contributor.author Garin Boronat, Olatz, 1979-ca
dc.contributor.author Ayuso Mateos, José Luisca
dc.contributor.author Almansa, Josuéca
dc.contributor.author Nieto, Martaca
dc.contributor.author Chatterji, Somnathca
dc.contributor.author Vilagut Saiz, Gemma, 1975-ca
dc.contributor.author Alonso Caballero, Jordica
dc.contributor.author Cieza, Alarcosca
dc.contributor.author Svetskova, Olgaca
dc.contributor.author Burger, Helenaca
dc.contributor.author Racca, Vittorioca
dc.contributor.author Francescutti, Carloca
dc.contributor.author Vieta, Eduardca
dc.contributor.author Kostanjsek, Nenadca
dc.contributor.author Raggi, Albertoca
dc.contributor.author Leonardi, Matildeca
dc.contributor.author Ferrer Forés, Maria Montserratca
dc.contributor.author MHADIE consortiumca
dc.date.accessioned 2015-06-12T07:37:48Z
dc.date.available 2015-06-12T07:37:48Z
dc.date.issued 2010ca
dc.description.abstract Background: The WHODAS-2 is a disability assessment instrument based on the conceptual framework of the International Classification of Functioning, Disability, and Health (ICF). It provides a global measure of disability and 7 domain-specific scores. The aim of this study was to assess WHODAS-2 conceptual model and metric properties in a set of chronic and prevalent clinical conditions accounting for a wide scope of disability in Europe. Methods: 1,119 patients with one of 13 chronic conditions were recruited in 7 European centres. Participants were clinically evaluated and administered the WHODAS-2 and the SF-36 at baseline, 6 weeks and 3 months of follow-up. The latent structure was explored and confirmed by factor analysis (FA). Reliability was assessed in terms of internal consistency (Cronbach's alpha) and reproducibility (intra-class correlation coefficients, ICC). Construct validity was evaluated by correlating the WHODAS-2 and SF-36 domains, and comparing known groups based on the clinical-severity and work status. Effect size (ES) coefficient was used to assess responsiveness. To assess reproducibility and responsiveness, subsamples of stable (at 6 weeks) and improved (after 3 moths) patients were defined, respectively, according to changes in their clinical-severity. Results: The satisfactory FA goodness of fit indexes confirmed a second order factor structure with 7 dimensions, and a global score for the WHODAS-2. Cronbach's alpha ranged from 0.77 (self care) to 0.98 (life activities: work or school), and the ICC was lower, but achieved the recommended standard of 0.7 for four domains. Correlations between global WHODAS-2 score and the different domains of the SF-36 ranged from -0.29 to -0.65. Most of the WHODAS-2 scores showed statistically significant differences among clinical-severity groups for all pathologies, and between working patients and those not working due to ill health (p < 0.001). Among the subsample of patients who had improved, responsiveness coefficients were small to moderate (ES = 0.3-0.7), but higher than those of the SF-36. Conclusions: The latent structure originally designed by WHODAS-2 developers has been confirmed for the first time, and it has shown good metric properties in clinic and rehabilitation samples. Therefore, considerable support is provided to the WHODAS-2 utilization as an international instrument to measure disability based on the ICF model.en
dc.description.sponsorship This study has been supported by the EC contract number SP24-CT-2004-513708 (MHADIE); by the Spanish Ministry of Health ISCIII FEDER (PI 061579, PI 051542, PI050036, and PI050206), CIBERSAM, CIBERESP, RETICS RD06/0011 (REM-TAP) and the Catalan Government DURSI-GENCAT (2005-SGR-00491), and AGAUR (2008FIC 00335).en
dc.format.mimetype application/pdfca
dc.identifier.citation Garin O, Ayuso-Mateos JL, Almansa J, Nieto M, Chatterji S, Vilagut G et al. Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases. Health Qual Life Outcomes. 2010;8:51. DOI: 10.1186/1477-7525-8-51ca
dc.identifier.doi http://dx.doi.org/10.1186/1477-7525-8-51
dc.identifier.issn 1477-7525ca
dc.identifier.uri http://hdl.handle.net/10230/23799
dc.language.iso engca
dc.publisher BioMed Centralca
dc.relation.ispartof Health and quality of life outcomes. 2010;8:51
dc.rights © 2010 Garin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.other Malalties cròniquesca
dc.subject.other Qualitat de vidaca
dc.title Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseasesen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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Articles (Departament de Medicina i Ciències de la Vida)
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