Cellular heterogeneity results from indirect effects under metabolic tradeoffs
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- dc.contributor.author Ollé-Vila, Aina
- dc.contributor.author Solé Vicente, Ricard, 1962-
- dc.date.accessioned 2019-11-06T10:51:43Z
- dc.date.available 2019-11-06T10:51:43Z
- dc.date.issued 2019
- dc.description.abstract The emergence and maintenance of multicellularity requires the coexistence of diverse cellular populations displaying cooperative relationships. This enables long-term persistence of cellular consortia, particularly under environmental constraints that challenge cell survival. Toxic environments are known to trigger the formation of multicellular consortia capable of dealing with waste while promoting cell diversity as a way to overcome selection barriers. In this context, recent theoretical studies suggest that an environment containing both resources and toxic waste can promote the emergence of complex, spatially distributed proto-organisms exhibiting division of labour and higher-scale features beyond the cell-cell pairwise interactions. Some previous non-spatial models suggest that the presence of a growth inhibitor can trigger the coexistence of competitive species in an antibiotic-resistance context. In this paper, we further explore this idea using both mathematical and computational models taking the most fundamental features of the proto-organisms model interactions. It is shown that this resource-waste environmental context, in which both species are lethally affected by the toxic waste and metabolic tradeoffs are present, favours the maintenance of diverse populations. A spatial, stochastic extension confirms our basic results. The evolutionary and ecological implications of these results are outlined.
- dc.format.mimetype application/pdf
- dc.identifier.citation Ollé-Vila A, Solé R. Cellular heterogeneity results from indirect effects under metabolic tradeoffs. R Soc Open Sci. 2019;6(9):190281. DOI: 10.1098/rsos.190281
- dc.identifier.doi http://dx.doi.org/10.1098/rsos.190281
- dc.identifier.issn 2054-5703
- dc.identifier.uri http://hdl.handle.net/10230/42754
- dc.language.iso eng
- dc.publisher Royal Society
- dc.relation.ispartof Royal Society Open Science. 2019;6(9):190281
- dc.rights © 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Biofilms
- dc.subject.keyword Heterogeneity
- dc.subject.keyword Multicellularity
- dc.subject.keyword Mutualism
- dc.subject.keyword Synthetic biology
- dc.title Cellular heterogeneity results from indirect effects under metabolic tradeoffs
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion