Association between polyphenol intake and breast Cancer risk by menopausal and hormone receptor status
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- dc.contributor.author Vitelli Storelli, Facundo
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Martín Sánchez, Vicente
- dc.date.accessioned 2020-06-15T06:43:48Z
- dc.date.available 2020-06-15T06:43:48Z
- dc.date.issued 2020
- dc.description.abstract There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56-0.89, Ptrend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59-0.93, Ptrend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57-0.93; Ptrend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.
- dc.format.mimetype application/pdf
- dc.identifier.citation Vitelli-Storelli F, Zamora-Ros R, Molina AJ, Fernández-Villa T, Castelló A, Barrio JP, et al. Association between polyphenol intake and breast Cancer risk by menopausal and hormone receptor status. Nutrients. 2020 Apr 3; 12(4):994. DOI: 10.3390/nu12040994
- dc.identifier.doi http://dx.doi.org/10.3390/nu12040994
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/44975
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2020 Apr 3;12(4):994
- dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Breast cancer
- dc.subject.keyword Case-control
- dc.subject.keyword Classes
- dc.subject.keyword Flavonoids
- dc.subject.keyword Intake
- dc.subject.keyword Polyphenols
- dc.title Association between polyphenol intake and breast Cancer risk by menopausal and hormone receptor status
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion