ctDNA to guide adjuvant therapy in localized colorectal cancer (CRC)
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- dc.contributor.author Masfarré, Laura
- dc.contributor.author Vidal Barrull, Joana
- dc.contributor.author Fernández Rodríguez, M. Concepción
- dc.contributor.author Montagut Viladot, Clara
- dc.date.accessioned 2022-07-21T06:28:05Z
- dc.date.available 2022-07-21T06:28:05Z
- dc.date.issued 2021
- dc.description.abstract Currently, the standard treatment for patients with localized colorectal cancer (CRC) includes surgical resection followed by adjuvant chemotherapy based on clinicopathological features. Recurrence risk stratification in those patients is of utmost importance to guide clinicians to avoid both under- and overtreatment. Recently, the concept of minimal residual disease (MRD) has emerged as the detection of circulating tumor DNA (ctDNA) carrying tumor-specific genomic or epigenomic alterations in the bloodstream of patients after surgery. Emerging studies described how the detection of MRD is a powerful prognostic biomarker to identify patients at higher risk of recurrence and who will potentially benefit the most from a systemic adjuvant treatment. Based on that unprecedented finding, several clinical trials involving stage II and III CRC patients are ongoing evaluating the impact of ctDNA guided treatment by escalating or deescalating adjuvant chemotherapy based on ctDNA MRD detection. This review provides a critical overview of current perspectives of liquid biopsy in early-stage CRC including technical, biological, and clinical key points, as well as ongoing ctDNA-based clinical trials that ultimately aim to improve clinical outcomes of patients with CRC.
- dc.format.mimetype application/pdf
- dc.identifier.citation Masfarré L, Vidal J, Fernández-Rodríguez C, Montagut C. ctDNA to guide adjuvant therapy in localized colorectal cancer (CRC). Cancers (Basel). 2021 Jun 8; 13(12): 2869. DOI: 10.3390/cancers13122869.
- dc.identifier.doi http://dx.doi.org/10.3390/cancers13122869
- dc.identifier.issn 2072-6694
- dc.identifier.uri http://hdl.handle.net/10230/53771
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2021 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Articles from Cancers are provided here courtesy of Multidisciplinary Digital Publishing Institute (MDPI)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0
- dc.subject.keyword Cancer detection
- dc.subject.keyword Circulating tumor DNA
- dc.subject.keyword Colorectal cancer
- dc.subject.keyword Liquid biopsy
- dc.subject.keyword Minimal residual disease
- dc.subject.keyword Next-generation sequencing
- dc.title ctDNA to guide adjuvant therapy in localized colorectal cancer (CRC)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion