Quality of life and the experience of living with early-stage Alzheimer's disease
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Villarejo-Galende, Alberto
- dc.contributor.author Puig-Pijoan, Albert
- dc.contributor.author Maurino, Jorge
- dc.date.accessioned 2023-02-01T07:39:36Z
- dc.date.available 2023-02-01T07:39:36Z
- dc.date.issued 2022
- dc.description.abstract Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score ≥22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.-1.0. The Quality of Life in Alzheimer 's Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment.
- dc.format.mimetype application/pdf
- dc.identifier.citation Villarejo-Galende A, García-Arcelay E, Piñol-Ripoll G, Del Olmo-Rodríguez A, Viñuela F, Boada M et al. Quality of life and the experience of living with early-stage Alzheimer's disease. J Alzheimers Dis. 2022;90(2):719-26. DOI: 10.3233/JAD-220696
- dc.identifier.doi http://dx.doi.org/10.3233/JAD-220696
- dc.identifier.issn 1387-2877
- dc.identifier.uri http://hdl.handle.net/10230/55512
- dc.language.iso eng
- dc.publisher IOS Press
- dc.relation.ispartof J Alzheimers Dis. 2022;90(2):719-26
- dc.rights © 2022 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Alzheimer’s disease
- dc.subject.keyword Amyloid
- dc.subject.keyword Biomarkers
- dc.subject.keyword Cerebrospinal fluid
- dc.subject.keyword Magnetic resonance imaging
- dc.subject.keyword Tau proteins
- dc.subject.keyword White matter hyperintensities
- dc.subject.keyword White matter lesions
- dc.title Quality of life and the experience of living with early-stage Alzheimer's disease
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion