Multiple environmental exposures in early-life and allergy-related outcomes in childhood

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• dc.contributor.author Granum, Berit
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Warembourg, Charline
• dc.contributor.author de Castro, Montserrat
• dc.contributor.author Donaire González, David
• dc.contributor.author Maitre, Léa
• dc.contributor.author Robinson, Oliver
• dc.contributor.author Tamayo-Uria, Ibon
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2021-02-03T07:28:29Z
• dc.date.available 2021-02-03T07:28:29Z
• dc.date.issued 2020
• dc.description.abstract Introduction: Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and methods: Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6-11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). Results: In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-iso-nonyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy. Discussion: This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash.
• dc.description.sponsorship This work was supported by the European Community’s Seventh Framework Programme [grant agreement no 308333—the HELIX project]; Instituto de Salud Carlos III; CIBERESP; Conselleria de Sanitat; Generalitat Valenciana; Department of Health of the Basque Government; Provincial Government of Gipuzkoa; Generalitat de Catalunya-CIRIT; Lithuanian Agency for Science Innovation and Technology [grant number 6-04-2014_31V-66]; Norwegian Ministry of Health and Care Services; Norwegian Ministry of Education and Research; Greek Ministry of Health; Ministerio de Ciencia Innovacion y Universidades [grant number MTM2015-68140-R]; Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII; Fondation de France.
• dc.format.mimetype application/pdf
• dc.identifier.citation Granum B, Oftedal B, Agier L, Siroux V, Bird P, Casas M et al. Multiple environmental exposures in early-life and allergy-related outcomes in childhood. Environ Int. 2020; 144:106038. DOI: 10.1016/j.envint.2020.106038
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2020.106038
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/46316
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2020; 144:106038
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.rights © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Allergic disease
• dc.subject.keyword Childhood
• dc.subject.keyword Environmental exposure
• dc.subject.keyword Exposome
• dc.subject.keyword Pregnancy
• dc.title Multiple environmental exposures in early-life and allergy-related outcomes in childhood
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion