Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts

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• dc.contributor.author Bazal, P.
• dc.contributor.author Gea, Alfredo
• dc.contributor.author Navarro, A. M.
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Corella, Dolores
• dc.contributor.author Alonso-Gómez, Ángel
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Muñoz-Bravo, Carlos
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Lapetra, José
• dc.contributor.author Serra Majem, Lluís
• dc.contributor.author Ros, Emilio
• dc.contributor.author Rekondo, Javier
• dc.contributor.author Muñoz, Miguel Ángel
• dc.contributor.author Basora, Josep
• dc.contributor.author Sorlí, José Vicente
• dc.contributor.author Toledo, Estefania
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Ruiz-Canela, Miguel
• dc.date.accessioned 2022-03-31T07:13:42Z
• dc.date.issued 2021
• dc.description.abstract Aims: The association between caffeinated coffee consumption and atrial fibrillation remains unclear. Recent studies suggest an inverse association only between a moderate caffeinated coffee consumption and atrial fibrillation, but others have reported no association. The aim of our study was to prospectively assess the association between caffeinated coffee consumption and atrial fibrillation in two Spanish cohorts, one of adults from a general population and another of elderly participants at high cardiovascular risk. Methods and results: We included 18,983 and 6479 participants from the 'Seguimiento Universidad de Navarra' (SUN) and 'Prevención con Dieta Mediterránea' (PREDIMED) cohorts, respectively. Participants were classified according to their caffeinated coffee consumption in three groups: ≤3 cups/month, 1-7 cups/week, and >1 cup/day. We identified 97 atrial fibrillation cases after a median follow-up of 10.3 years (interquartile range 6.5-13.5), in the SUN cohort and 250 cases after 4.4 years median follow-up (interquartile range 2.8-5.8) in the PREDIMED study. No significant associations were observed in the SUN cohort although a J-shaped association was suggested. A significant inverse association between the intermediate category of caffeinated coffee consumption (1-7 cups/week) and atrial fibrillation was observed in PREDIMED participants with a multivariable-adjusted hazard ratio = 0.53 (95% confidence interval 0.36-0.79) when compared with participants who did not consume caffeinated coffee or did it only occasionally. No association was found for higher levels of caffeinated coffee consumption (>1 cup per day), hazard ratio = 0.79 (95% confidence interval 0.49-1.28). In the meta-analysis of both PREDIMED and SUN studies, the hazard ratio for intermediate consumption of caffeinated coffee was 0.60 (95% confidence interval 0.44-0.82) without evidence of heterogeneity. Similar findings were found for the association between caffeine intake and atrial fibrillation risk. Conclusion: Intermediate levels of caffeinated coffee consumption (1-7 cups/week) were associated with a reduction in atrial fibrillation risk in two prospective Mediterranean cohorts.
• dc.description.sponsorship The author(s) received no financial support for the research, authorship, and/or publication of this article and had full access to all of the data in this study. The SUN Project was supported by the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (RD 06/0045, PI14/ 01798, PI14/01764, PI17/01795), the Navarra Regional Government, and the University of Navarra. An Advanced Research Grant from the European Research Council to Miguel A Martínez-González (agreement #340918-PREDIMED-Plus) is duly acknowledged. PREDIMED trial was supported by the official funding agency for biomedical research of the Spanish government (Instituto de Salud Carlos III) RTIC G03/140 (Coordinator: Dr Estruch) and RTIC RD 06/0045 (Coordinator: Dr Martínez-González). We also acknowledge grants from the National Institutes of Health, United States (1R01HL118264-01); Fondo de Investigación Sanitaria Fondo Europeo de Desarrollo Regional (PI04/0233, PI05/0976, PI07/0240, PI10/01407, PI10/02658, PI11/00049, PI11/02505 and AGL2010-22319-C03-03); Consejería de Salud de la Junta de Andalucía (PI0105/2007), and by the Generalitat Valenciana, Spain (ACOMP/2013/165 and ACOMP/2013/159).
• dc.format.mimetype application/pdf
• dc.identifier.citation Bazal P, Gea A, Navarro AM, Salas-Salvadó J, Corella D, Alonso-Gómez A, Fitó M, Muñoz-Bravo C, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Rekondo J, Muñoz MA, Basora J, Sorlí JV, Toledo E, Martínez-González MA, Ruiz-Canela M. Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts. Eur J Prev Cardiol. 2021 May 22;28(6):648-57. DOI: 10.1177/2047487320909065
• dc.identifier.doi http://dx.doi.org/10.1177/2047487320909065
• dc.identifier.issn 2047-4873
• dc.identifier.uri http://hdl.handle.net/10230/52804
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Eur J Prev Cardiol. 2021 May 22;28(6):648-57
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in European journal of preventive cardiology following peer review. The version of record Bazal P, Gea A, Navarro AM, Salas-Salvadó J, Corella D, Alonso-Gómez A, Fitó M, Muñoz-Bravo C, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Rekondo J, Muñoz MA, Basora J, Sorlí JV, Toledo E, Martínez-González MA, Ruiz-Canela M. Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts. Eur J Prev Cardiol. 2021 May 22;28(6):648-57. DOI: 10.1177/2047487320909065 is available online at: http://dx.doi.org/10.1177/2047487320909065.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Atrial fibrillation
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Caffeine
• dc.subject.keyword Coffee
• dc.title Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion