Frequency and severity of potential drug interactions in a cohort of HIV-infected patients Identified through a Multidisciplinary team

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  • dc.contributor.author Molas, Ema
  • dc.contributor.author Luque Pardos, Sònia
  • dc.contributor.author Retamero, A.
  • dc.contributor.author Echeverría Esnal, Daniel
  • dc.contributor.author Guelar Grinberg, Ana
  • dc.contributor.author Montero, Maria Milagro
  • dc.contributor.author Güerri Fernández, Roberto
  • dc.contributor.author Sorli Redó, M. Luisa
  • dc.contributor.author Lerma-Chippirraz, Elisabet
  • dc.contributor.author Villar García, Judit
  • dc.contributor.author Knobel Freud, Hernando
  • dc.date.accessioned 2018-11-19T08:54:25Z
  • dc.date.issued 2018
  • dc.description.abstract OBJECTIVES: Interactions between antiretroviral treatment (ART) and comedications are a concern in HIV-infected patients. This study aimed to determine the frequency and severity of potential drug-drug interactions (PDDIs) with ART in our setting. METHODS: Observational study by a multidisciplinary team in 1259 consecutive HIV patients (March 2015-September 2016). Data on demographics, toxic habits, comorbidities, and current ART were collected. A structured questionnaire recorded concomitant medications (including occasional and over-the-counter drugs). PDDIs were classified into four categories: (1) no interactions, (2) mild (clinically non-significant), (3) moderate (requiring close monitoring or drug modification/dose adjustment), and (4) severe (contraindicated). STATISTICAL ANALYSIS: chi-square test, logistic regression analysis. RESULTS: In total, 881 (70%) patients took comedication, and 563 (44.7%) had ≥ PDDI. Forty-one comedicated patients (4.6%) had severe and 522 (59.2%) moderate PDDIs. Moderate PDDIs mainly involved cardiovascular (53.8%) and central nervous system (40.2%) drugs. Independent risk factors for PDDIs were ART containing a boosted protease inhibitor (odds ratio [OR]=9.11, 95% confidence interval [CI] 5.15-16.11; p = 0.0001) and/or non-nucleoside reverse transcriptase (NNRTI) (OR = 4.34, 95%CI 2.49-7.55; p = 0.0001), HCV co-infection (OR = 3.26, 95%CI 2.15-4.93; p = 0.0001), and use of two or more comedications (OR = 3.36, 95%CI 2.27-4.97; p = 0.0001). Adherence and effectiveness of ART were similar in patients with and without PDDIs. The team made 133 recommendations related to comedications (drug change or dose adjustment) or ART (drug switch or change in administration schedule). CONCLUSIONS: Systematic evaluation detected a significant percentage of PDDIs requiring an intervention in HIV patients on ART. Monitoring and advice about drug-drug interactions should be part of routine practice.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Molas E, Luque S, Retamero A, Echeverría-Esnal D, Guelar A, Montero M. et al. Frequency and severity of potential drug interactions in a cohort of HIV-infected patients Identified through a multidisciplinary team. HIV Clin Trials. 2018 Feb;19(1):1-7. DOI: 10.1080/15284336.2017.1404690
  • dc.identifier.doi http://dx.doi.org/10.1080/15284336.2017.1404690
  • dc.identifier.issn 1528-4336
  • dc.identifier.uri http://hdl.handle.net/10230/35784
  • dc.language.iso eng
  • dc.publisher Taylor & Francis (Routledge)
  • dc.relation.ispartof HIV Clinical Trials. 2018 Feb;19(1):1-7
  • dc.rights © Taylor & Francis. This is an electronic version of an article published in olas E, Luque S, Retamero A, Echeverría-Esnal D, Guelar A, Montero M. et al. Frequency and severity of potential drug interactions in a cohort of HIV-infected patients Identified through a multidisciplinary team. HIV Clin Trials. 2018 Feb;19(1):1-7. HIV Clin Trials is available online at: https://www.tandfonline.com/doi/full/10.1080/15284336.2017.1404690.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword AIDS
  • dc.subject.keyword Concomitant medications
  • dc.subject.keyword Drug–drug interactions
  • dc.subject.keyword HIV
  • dc.subject.keyword Highly active antiretroviral therapy
  • dc.subject.other VIH (Virus)
  • dc.subject.other Sida -- Tractament
  • dc.subject.other Medicaments -- Interacció
  • dc.title Frequency and severity of potential drug interactions in a cohort of HIV-infected patients Identified through a Multidisciplinary team
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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