Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD

Stankeviciute, Laura; Falcón, Carles; Operto, Grégory; Garcia, Marina; Shekari, Mahnaz; Iranzo, Alex; Niñerola-Baizán, Aida; Perissinotti, Andrés; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Cacciaglia, Raffaele; Gispert López, Juan Domingo; Grau-Rivera, Oriol; ALFA Study

Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Stankeviciute, Laura
dc.contributor.author Falcón, Carles
dc.contributor.author Operto, Grégory
dc.contributor.author Garcia, Marina
dc.contributor.author Shekari, Mahnaz
dc.contributor.author Iranzo, Alex
dc.contributor.author Niñerola-Baizán, Aida
dc.contributor.author Perissinotti, Andrés
dc.contributor.author Minguillón, Carolina
dc.contributor.author Fauria, Karine
dc.contributor.author Molinuevo, José Luis
dc.contributor.author Zetterberg, Henrik
dc.contributor.author Blennow, Kaj
dc.contributor.author Suárez-Calvet, Marc
dc.contributor.author Cacciaglia, Raffaele
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author Grau-Rivera, Oriol
dc.contributor.author ALFA Study
dc.date.accessioned 2023-09-08T06:27:51Z
dc.date.available 2023-09-08T06:27:51Z
dc.date.issued 2023
dc.description.abstract Introduction: Poor sleep quality is associated with cognitive outcomes in Alzheimer's disease (AD). We analyzed the associations between self-reported sleep quality and brain structure and function in cognitively unimpaired (CU) individuals. Methods: CU adults (N = 339) underwent structural magnetic resonance imaging, lumbar puncture, and the Pittsburgh Sleep Quality Index (PSQI) questionnaire. A subset (N = 295) performed [18F] fluorodeoxyglucose positron emission tomography scans. Voxel-wise associations with gray matter volumes (GMv) and cerebral glucose metabolism (CMRGlu) were performed including interactions with cerebrospinal fluid (CSF) AD biomarkers status. Results: Poorer sleep quality was associated with lower GMv and CMRGlu in the orbitofrontal and cingulate cortices independently of AD pathology. Self-reported sleep quality interacted with altered core AD CSF biomarkers in brain areas known to be affected in preclinical AD stages. Discussion: Poor sleep quality may impact brain structure and function independently from AD pathology. Alternatively, AD-related neurodegeneration in areas involved in sleep-wake regulation may induce or worsen sleep disturbances. Highlights Poor sleep impacts brain structure and function independent of Alzheimer's disease (AD) pathology. Poor sleep exacerbates brain changes observed in preclinical AD. Sleep is an appealing therapeutic strategy for preventing AD.
dc.description.sponsorship This publication is part of the ALFA study (Alzheimer and Families). The authors would like to express their most sincere gratitude to the ALFA project participants and relatives, without whom this research would have not been possible. The authors thank Roche Diagnostics International Ltd. for providing the kits to measure CSF biomarkers and GE Healthcare for providing the doses for [18F]flutemetamol PET. H.Z. is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2018-02532), the European Research Council (#681712 and #101053962), Swedish State Support for Clinical Research (#ALFGBG-71320), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), the AD Strategic Fund and the Alzheimer's Association (#ADSF-21-831376-C, #ADSF-21-831381-C, and #ADSF-21-831377-C), the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen för Gamla Tjänarinnor, Hjärnfonden, Sweden (#FO2022-0270), the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860197 (MIRIADE), the European Union Joint Programme – Neurodegenerative Disease Research (JPND2021-00694), and the UK Dementia Research Institute at UCL (UKDRI-1003). Collaborators of the ALFA Study are Müge Akinci, Annabella Beteta, Alba Cañas, Irene Cumplido, Carme Deulofeu, Ruth Dominguez, Maria Emilio, Karine Fauria, Sherezade Fuentes, Oriol Grau-Rivera, Laura Hernandez, Gema Huesa, Jordi Huguet, Eider M. Arenaza-Urquijo, Paula Marne, Tania Menchón, Carolina Minguillon, Eva M. Palacios, Eleni Palpatzis, Cleofé Peña-Gómez, Albina Polo, Sandra Pradas, Blanca Rodríguez-Fernández, Aleix Sala-Vila, Gemma Salvadó, Mahnaz Shekari, Anna Soteras, Laura Stankeviciute, Marc Vilanova, and Natalia Vilor-Tejedor. This work was supported by a grant from the Alzheimer's Association (2019-AARF-644568) awarded to O.G.-R. The ALFASleep study also receives funding from the Instituto de Salud Carlos III through the project PI19/00117 (co-funded by European Regional Development Fund; “A way to make Europe”) awarded to OG-R. The ALFA+ study is funded by the “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004 and the Alzheimer's Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17-519007). O.G.-R. is supported by the Spanish Ministry of Science, Innovation and Universities (IJC2020-043417-I).
dc.format.mimetype application/pdf
dc.identifier.citation Stankeviciute L, Falcon C, Operto G, Garcia M, Shekari M, Iranzo Á, Niñerola-Baizán A, Perissinotti A, Minguillón C, Fauria K, Molinuevo JL, Zetterberg H, Blennow K, Suárez-Calvet M, Cacciaglia R, Gispert JD, Grau-Rivera O, ALFA study. Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD. Alzheimers Dement. 2023 Dec;19(12):5371-86. DOI: 10.1002/alz.13102
dc.identifier.doi http://dx.doi.org/10.1002/alz.13102
dc.identifier.issn 1552-5260
dc.identifier.uri http://hdl.handle.net/10230/57836
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Alzheimers Dement. 2023 Dec;19(12):5371-86
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/681712
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101053962
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/860197
dc.rights © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Cerebrospinal fluid biomarkers
dc.subject.keyword Fluorodeoxyglucose positron emission tomography
dc.subject.keyword Preclinical Alzheimer's disease
dc.subject.keyword Sleep
dc.subject.keyword Structural magnetic resonance imaging
dc.title Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)