Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

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• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Kovatcheva, Marta
• dc.contributor.author Casas, Rosa
• dc.contributor.author Toledo, Estefania
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Ros, Emilio
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Serrano, Manuel
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.date.accessioned 2024-05-27T06:20:44Z
• dc.date.available 2024-05-27T06:20:44Z
• dc.date.issued 2024
• dc.description.abstract Background: Vitamin B12 is an essential nutrient that is involved in numerous physiological processes, and its deficiency can lead to various complications, including neurological and haematological disorders. Some studies have suggested that vitamin B12 may have anti-inflammatory effects, but the mechanisms underlying this relationship are not yet fully understood. We investigated the relationship between circulating vitamin B12 and inflammatory markers interleukin (IL)-6 and C-reactive protein (CRP). The association of peripheral levels of vitamin B12 with IL-6 and CRP was assessed in 136 human samples from a high cardiovascular risk population. To corroborate the results from the human trial, the analysis was replicated in naturally aged mice. Results: Individuals with higher serum levels of vitamin B12 showed lower concentrations of IL-6 and CRP after adjustment for potential confounders, and an inverse association was also found between serum IL-6 and vitamin B12 levels in naturally aged mice. Conclusion: Circulating vitamin B12 was inversely associated with IL-6 and CRP in humans and with IL-6 in mice, suggesting that it may exert an anti-inflammatory effect through modulation of these pro-inflammatory molecules. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
• dc.description.sponsorship This research was partially funded by PID2020-114022RB-I00 and CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (AEI/FEDER, UE) and Generalitat de Catalunya (GC) [2021-SGR-00334]. INSA-UB is María de Maeztu Unit of Excellence (grant CEX2021-001234-M funded by MICIN/AEI/FEDER, UE). Work in the laboratory of M. Serrano was funded by the IRB and La Caixa Foundation, and by grants from the Spanish Ministry of Science cofunded by the European Regional Development Fund (SAF-2017-82613-R, RTC-2017-6123-1), the European Research Council (ERC-2014-AdG/669622), Secretaria d'Universitats i Recerca del Departament d'Empresa i Coneixement of Catalonia (Grup de Recerca consolidat 2017 SGR 282) and the AECC (PRYCO211023SERR). M. Kovatcheva reports grants from Asociación Española Contra el Cáncer (AECC), the European Research Council and IRB BioMedTec during the conduct of the study, as well as other support from Galapagos NV outside the submitted work. M. Serrano reports grants from the Spanish Ministry of Science, the European Research Council, La Caixa Foundation, the Spanish Association for Cancer Research (AECC) and Departament d'Empresa i Coneixement of Catalonia during the conduct of the study, as well as other support from Senolytic Therapeutics, Inc., Rejuveron Senescence Therapeutics, AG, Life Biosciences, Inc., Altos Labs, Inc. and Galapagos NV, and grants from the Milky Way Research Foundation outside the submitted work. The PREDIMED trial was supported by the official funding agency for biomedical research of the Spanish government (Instituto de Salud Carlos III) through grants provided to research networks specifically developed for the trial: RTIC G03/140 (Coordinator: RE) and RTIC RD 06/0045. All investigators of the PREDIMED trial belong to Centro de Investigación Biomédica en Red (CIBER), an initiative of Instituto de Salud Carlos III. ID-L thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU20/02478) contract.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, Ros E, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024 Jan 30;104(2):875-82. DOI: 10.1002/jsfa.12976
• dc.identifier.doi http://dx.doi.org/10.1002/jsfa.12976
• dc.identifier.issn 0022-5142
• dc.identifier.uri http://hdl.handle.net/10230/60244
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof J Sci Food Agric. 2024 Jan 30;104(2):875-82
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/669622
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2021-001234-M
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-82613-R
• dc.rights © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword C-reactive protein
• dc.subject.keyword PREDIMED trial
• dc.subject.keyword Bioactive compounds
• dc.subject.keyword Inflammation
• dc.subject.keyword Intereukin-6
• dc.subject.keyword Micronutrients
• dc.title Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion