Regulation of muscle stem cell functions: a focus on the p38 MAPK signaling pathway
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- dc.contributor.author Segalés Dalmau, Jessicaca
- dc.contributor.author Perdiguero, Eusebio, 1968-ca
- dc.contributor.author Muñoz Cánoves, Pura, 1962-ca
- dc.date.accessioned 2018-05-14T07:47:35Z
- dc.date.available 2018-05-14T07:47:35Z
- dc.date.issued 2016
- dc.description.abstract Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury in the adult constitutes an excellent paradigm to investigate the mechanisms whereby environmental cues control gene expression programs in muscle stem cells (satellite cells) by acting on transcriptional and epigenetic effectors. Here we will review the molecular mechanisms implicated in the transition of satellite cells throughout the distinct myogenic stages (i.e., activation from quiescence, proliferation, differentiation, and self-renewal). We will also discuss recent findings on the causes underlying satellite cell functional decline with aging. In particular, our review will focus on the epigenetic changes underlying fate decisions and on how the p38 MAPK signaling pathway integrates the environmental signals at the chromatin to build up satellite cell adaptive responses during the process of muscle regeneration, and how these responses are altered in aging. A better comprehension of the signaling pathways connecting external and intrinsic factors will illuminate the path for improving muscle regeneration in the aged.
- dc.description.sponsorship Work in the authors' laboratory was supported by MINECO, Spain (SAF2015-67369-R, “María de Maeztu” Programme for Units of Excellence in R&D MDM-2014-0370), AFM, MDA, Convenio UPF-CNIC, E-RARE, Fundació Marató TV3. JS is recipient of a Juan de la Cierva postdoctoral fellowship.
- dc.format.mimetype application/pdf
- dc.identifier.citation Segalés J, Perdiguero E, Muñoz-Cánoves P. Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway. Front Cell Dev Biol. 2016 Aug 30;4:91. DOI: 10.3389/fcell.2016.00091
- dc.identifier.doi http://dx.doi.org/10.3389/fcell.2016.00091
- dc.identifier.issn 2296-634X
- dc.identifier.uri http://hdl.handle.net/10230/34621
- dc.language.iso eng
- dc.publisher Frontiersca
- dc.relation.ispartof Front Cell Dev Biol. 2016 Aug 30;4:91
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
- dc.rights © 2016 Segalés, Perdiguero and Muñoz-Cánoves. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Aging
- dc.subject.keyword Epigenetics
- dc.subject.keyword Muscle stem cells
- dc.subject.keyword P38 MAPKs
- dc.subject.keyword Satellite cells
- dc.subject.keyword Tissue regeneration
- dc.title Regulation of muscle stem cell functions: a focus on the p38 MAPK signaling pathwayca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion