Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia

Climent Biescas, Elisenda; Pérez-Calahorra, Sofía; Marco-Benedí, Victoria; Plana, Nuria; Sánchez, Rosa; Ros, Emilio; Ascaso Gimilio, Juan Francisco; Puzo, José; Almagro, Fátima; Lahoz, Carlos; Civeira, Fernando; Pedro-Botet, Juan Carlos

Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia

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dc.contributor.author Climent Biescas, Elisendaca
dc.contributor.author Pérez-Calahorra, Sofíaca
dc.contributor.author Marco-Benedí, Victoriaca
dc.contributor.author Plana, Nuriaca
dc.contributor.author Sánchez, Rosaca
dc.contributor.author Ros, Emilioca
dc.contributor.author Ascaso Gimilio, Juan Franciscoca
dc.contributor.author Puzo, Joséca
dc.contributor.author Almagro, Fátimaca
dc.contributor.author Lahoz, Carlosca
dc.contributor.author Civeira, Fernandoca
dc.contributor.author Pedro-Botet, Juan Carlosca
dc.date.accessioned 2018-07-24T09:38:12Z
dc.date.available 2018-07-24T09:38:12Z
dc.date.issued 2017
dc.description.abstract Patients with heterozygous familial hypercholesterolemia (HeFH) have been reported to be less vulnerable to type 2 diabetes mellitus (T2DM), although the mechanism is unknown. The aims of the present study were to assess the effects of low density lipoprotein (LDL) cholesterol concentration and the presence of FH-causing mutations on T2DM prevalence in HeFH. Data were collected from the Dyslipidemia Registry of the Spanish Arteriosclerosis Society. Inclusion criteria were definite or probable HeFH in patients aged ≥18 years. T2DM prevalence in HeFH patients was compared with data of the general population. 1732 patients were included. The prevalence of T2DM was lower in patients with HeFH compared with the general population (5.94% vs 9.44%; OR: 0.606, 95% CI 0.486-0.755, p < 0.001). Risk factors for developing T2DM were male sex, age, body mass index, hypertension, baseline triglyceride levels and years on statin therapy. The prevalence of T2DM in HeFH patients was 40% lower than that observed in the general population. Gene mutations and LDL cholesterol concentrations were not risk factors associated with the prevalence of T2DM in patients with HeFH. The prevalence of T2DM in patients with HeFH was 40% lower than in the general population matched for age and sex.
dc.format.mimetype application/pdf
dc.identifier.citation Climent E, Pérez-Calahorra S, Marco-Benedí V, Plana N, Sánchez R, Ros E. et al. Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia. Sci Rep. 2017 Jul 17;7(1):5596. DOI: 10.1038/s41598-017-06101-6
dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-06101-6
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/35247
dc.language.iso eng
dc.publisher Nature Publishing Groupca
dc.relation.ispartof Scientific Reports. 2017 Jul 17;7(1):5596
dc.rights Copyright © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Colesterol
dc.subject.other Diabetis
dc.subject.other Hipercolesterolèmia
dc.title Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemiaca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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