Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients

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• dc.contributor.author Sanz Latiesas, Javier, 1967-
• dc.contributor.author Zhao, Min
• dc.contributor.author Rodríguez de Dios, Núria
• dc.contributor.author Granado Carrasco, Raquel
• dc.contributor.author Foro Arnalot, Palmira
• dc.contributor.author Reig, Anna
• dc.contributor.author Membrive, Ismael
• dc.contributor.author Algara López, Manuel-Ignacio
• dc.date.accessioned 2019-03-08T09:56:12Z
• dc.date.available 2019-03-08T09:56:12Z
• dc.date.issued 2018
• dc.description.abstract PURPOSE: Radiation therapy is a key treatment of breast cancer. Elderly patients with associated diseases that modify their performance status do not tolerate long periods of daily irradiation. The objective of this study is to analyze the results of weekly hypofractionated treatment in these patients. MATERIAL AND METHODS: Between 1992 and 2016, we included 486 elderly patients presenting concomitant pathology or sociofamilial problems in which it was not feasible to propose conventional treatment. They were treated with conservative surgery or mastectomy and then adjuvant hypofractionated irradiation, administering 5 Gy or 6.25 Gy in 6 fractions, once a week (total dose 30-37.5 Gy) over 6 weeks. RESULTS: Breast cancer overall survival according to the Kaplan-Meier method at 5 years was 74.2% ± 2.3%; breast cancer disease-free survival was 90% ± 1.6%; local relapse-free survival was 96.5% ± 1% showing that patients die more from other causes and not from their neoplasia. Acute dermatitis was mild (75.6% of the patients grades I-III) and 30.6% had moderate chronic fibrosis. CONCLUSIONS: the once-weekly hypofractionated radiotherapy is a feasible and convenient option for elderly patients with breast cancer. It is a safe treatment modality with similar survival and local control results compared to standard fractionation, while the side effects are acceptable.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sanz J, Zhao M, Rodríguez N, Granado R, Foro P, Reig A. et al. Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients. Biomed Res Int. 2018 Mar 15;2018:8321871. DOI: 10.1155/2018/8321871
• dc.identifier.doi http://dx.doi.org/10.1155/2018/8321871
• dc.identifier.issn 2314-6141
• dc.identifier.uri http://hdl.handle.net/10230/36776
• dc.language.iso eng
• dc.publisher Hindawi
• dc.relation.ispartof BioMed Research International. 2018 Mar 15;2018:8321871
• dc.rights Copyright © 2018 Javier Sanz et al. This is an open access article distributed under the Creative Commons Attribution License,https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Articles from BioMed Research International are provided here courtesy of Hindawi Limited
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Mama -- Càncer -- Tractament
• dc.subject.other Persones grans -- Càncer
• dc.subject.other Radioteràpia
• dc.title Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion