Genomic analysis of Andamanese provides insights into ancient human migration into Asia and adaptation

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• dc.contributor.author Mondal, Mayukh, 1989-ca
• dc.contributor.author Casals López, Ferranca
• dc.contributor.author Xu, Tinaca
• dc.contributor.author Dall'Olio, Giovanni Marco, 1983-ca
• dc.contributor.author Pybus Oliveras, Marc, 1985-ca
• dc.contributor.author Netea, Mihai Gca
• dc.contributor.author Comas, David, 1969-ca
• dc.contributor.author Laayouni, Hafid, 1968-ca
• dc.contributor.author Li, Qibinca
• dc.contributor.author Majumder, Partha P.ca
• dc.contributor.author Bertranpetit, Jaume, 1952-ca
• dc.date.accessioned 2018-04-19T09:22:41Z
• dc.date.available 2018-04-19T09:22:41Z
• dc.date.issued 2016
• dc.description.abstract To shed light on the peopling of South Asia and the origins of the morphological adaptations found there, we analyzed whole-genome sequences from 10 Andamanese individuals and compared them with sequences for 60 individuals from mainland Indian populations with different ethnic histories and with publicly available data from other populations. We show that all Asian and Pacific populations share a single origin and expansion out of Africa, contradicting an earlier proposal of two independent waves of migration. We also show that populations from South and Southeast Asia harbor a small proportion of ancestry from an unknown extinct hominin, and this ancestry is absent from Europeans and East Asians. The footprints of adaptive selection in the genomes of the Andamanese show that the characteristic distinctive phenotypes of this population (including very short stature) do not reflect an ancient African origin but instead result from strong natural selection on genes related to human body size.
• dc.description.sponsorship The main funding was provided by the joint Spain–India bilateral grant PRI-PIBIN-2011-0942 from the Ministerio de Economía y Competitividad (Spain). Complementary funding was provided by grant BFU2013-43726-P from the Ministerio de Economía y Competitividad (Spain), with the support of Secretaria d'Universitats i Recerca, Departament d'Economia i Coneixement de la Generalitat de Catalunya (GRC 2014 SGR866)
• dc.format.mimetype application/pdf
• dc.identifier.citation Mondal M, Casals F, Xu T, Dall'Olio GM, Pybus M, Netea MG et al. Genomic analysis of Andamanese provides insights into ancient human migration into Asia and adaptation. Nat Genet. 2016 Sep;48(9):1066-70. DOI: 10.1038/ng.3621
• dc.identifier.doi http://dx.doi.org/10.1038/ng.3621
• dc.identifier.issn 1061-4036
• dc.identifier.uri http://hdl.handle.net/10230/34401
• dc.language.iso eng
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Nature Genetics. 2016 Sep;48(9):1066-70
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726-P
• dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/ng.3621
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Adaptació (Fisiologia)
• dc.subject.other Marcadors genètics
• dc.subject.other Genètica humana -- Variació
• dc.subject.other Genètica de poblacions
• dc.subject.other Migració humana
• dc.subject.other Genètica
• dc.title Genomic analysis of Andamanese provides insights into ancient human migration into Asia and adaptationca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion