Association of IGF-1 CA(n) and IGFBP3 rs2854746 polymorphisms with endometrial polyp risk

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• dc.contributor.author Silva Doria, Pedro Leopoldo
• dc.contributor.author Moscovitz, Thomas
• dc.contributor.author Tcherniakovsky, Marcos
• dc.contributor.author Fernandes, Cesar Eduardo
• dc.contributor.author Pompei, Luciano Melo
• dc.contributor.author Wajman, Milton
• dc.contributor.author Nimwegen, Angela Van
• dc.contributor.author Haimovich Segal, Sergio Mario
• dc.date.accessioned 2019-03-11T09:11:56Z
• dc.date.available 2019-03-11T09:11:56Z
• dc.date.issued 2018
• dc.description.abstract INTRODUCTION: Insulin-like growth factor 1 (IGF-1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of IGF-1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). Genetic variations influence the levels of IGF-1 and IGFBP3. The purpose of this study was to examine the association of polymorphisms IGF-1 CA(n) and IGFBP3 rs2854746 with risk of endometrial polyps. MATERIALS AND METHODS: Case control observational study, composed of 104 women with antecedent of endometrial polyp (case group) and 81 postmenopausal women without antecedent of endometrial diseases (control group). Genotyping of IGF-1 CA(n) was performed by PCR and fragment analysis by capillary electrophoresis, and genotyping of IGFBP3 rs2854746 was performed by PCR-HRM. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. RESULTS: The genotype IGF-1 CA(19)/CA(19) was associated with an increased endometrial polyp risk (OR=2,57; IC 95%= 1,09 - 6,01); this was also found when combining it with CA(>19)/CA(n) genotypes (OR=2,18; IC 95%= 1,06-4,47). The IGFBP3 rs2854746 analyses showed the CG genotype having a protective effect for endometrial polyp (OR=0,37; IC 95%= 0,19-0,73), fact also observed when grouping CG and GG carriers (OR=0,51; IC 95%= 0,28-0,93). CONCLUSION: The genotypes CA(19)/CA(19) and CA(19)/CA(19) + CA(>19)/CA(n) of the IGF-1 CA(n) may be considered a risk for endometrial polyp, whereas the genotypes CG and CG + GG of IGFBP3 rs2854746 polymorphism have an inverse effect of endometrial polyp risk.
• dc.format.mimetype application/pdf
• dc.identifier.citation Silva-Doria PL, Moscovitz T, Tcherniakovsky M, Fernandes CE, Pompei LM, Wajman M. et al. Association of IGF-1 CA(n) and IGFBP3 rs2854746 polymorphisms with endometrial polyp risk. Biomed Res Int. 2018 Dec 13; 2018:8704346. DOI: 10.1155/2018/8704346
• dc.identifier.doi http://dx.doi.org/10.1155/2018/8704346
• dc.identifier.issn 2314-6141
• dc.identifier.uri http://hdl.handle.net/10230/36786
• dc.language.iso eng
• dc.publisher Hindawi
• dc.relation.ispartof BioMed Research International. 2018 Dec 13;2018:8704346
• dc.rights Copyright © 2018 Pedro Leopoldo Silva Doria et al. This is an open access article distributed under the https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Pòlips (Patologia)
• dc.subject.other Endometri--Malalties--Diagnòstic
• dc.subject.other Genotip
• dc.title Association of IGF-1 CA(n) and IGFBP3 rs2854746 polymorphisms with endometrial polyp risk
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion