Measuring and modeling interventions in aging

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  • dc.contributor.author Stroustrup, Nicholas
  • dc.date.accessioned 2019-11-13T11:18:39Z
  • dc.date.available 2019-11-13T11:18:39Z
  • dc.date.issued 2018
  • dc.description.abstract Many dietary, pharmaceutical, and genetic interventions have been found to increase the lifespan of laboratory animals. Several are now being explored for clinical application. To understand the physiologic action and therapeutic potential of interventions in aging, researchers must build quantitative models. Do interventions delay the onset of aging? Slow it down? Merely ameliorate some of its symptoms? If interventions slow some aging mechanisms but accelerate others, can we detect or predict the systemic consequences? Statistical and analytic models provide a crucial framework in which to answer these questions and clarify the systems-level effect of molecular interventions in aging. This review provides a brief survey of approaches to modeling lifespan data and places them in the context of recent experimental work.
  • dc.description.sponsorship This work was supported by the MEIC Excelencia award BFU2017-88615-P, and by an award from the Glenn Foundation for Medical Research.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Stroustrup N. Measuring and modeling interventions in aging. Curr Opin Cell Biol. 2018;55:129-38. DOI: 10.1016/j.ceb.2018.07.004
  • dc.identifier.doi http://dx.doi.org/10.1016/j.ceb.2018.07.004
  • dc.identifier.issn 0955-0674
  • dc.identifier.uri http://hdl.handle.net/10230/42835
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Current Opinion in Cell Biology. 2018;55:129-38
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-88615-P
  • dc.rights © 2018, Nicholas Stroustrup. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.title Measuring and modeling interventions in aging
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)