Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
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- dc.contributor.author Comín Colet, Josep
- dc.contributor.author Enjuanes Grau, Cristina
- dc.contributor.author González, Gina
- dc.contributor.author Torrens, Ainhoa
- dc.contributor.author Cladellas, Mercè
- dc.contributor.author Meroño, Oona
- dc.contributor.author Ribas Barquet, Núria
- dc.contributor.author Ruiz, Sonia
- dc.contributor.author Gómez, Miquel
- dc.contributor.author Verdú-Rotellar, José María
- dc.contributor.author Bruguera-Cortada, Jordi
- dc.date.accessioned 2025-01-22T16:36:29Z
- dc.date.available 2025-01-22T16:36:29Z
- dc.date.issued 2013
- dc.description.abstract Aims: To evaluate the effect of iron deficiency (ID) and/or anaemia on health-related quality of life (HRQoL) in patients with chronic heart failure (CHF). Methods and results: We undertook a post-hoc analysis of a cohort of CHF patients in a single-centre study evaluating cognitive function. At recruitment, patients provided baseline information and completed the Minnesota Living with Heart Failure questionnaire (MLHFQ) for HRQoL (higher scores reflect worse HRQoL). At the same time, blood samples were taken for serological evaluation. ID was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. Anaemia was defined as haemoglobin ≤12 g/dL. A total of 552 CHF patients were eligible for inclusion, with an average age of 72 years and 40% in NYHA class III or IV. The MLHFQ overall summary scores were 41.0 ± 24.7 among those with ID, vs. 34.4 ± 26.4 for non-ID patients (P = 0.003), indicating worse HRQoL. When adjusted for other factors associated with HRQoL, ID was significantly associated with worse MLHFQ overall summary (P = 0.008) and physical dimension scores (P = 0.002), whereas anaemia was not (both P > 0.05). Increased levels of soluble transferrin receptor were also associated with impaired HRQoL (P ≤ 0.001). Adjusting for haemoglobin and C-reactive protein, ID was more pronounced in patients with anaemia compared with those without (P < 0.001). Conclusion: In patients with CHF, ID but not anaemia was associated with reduced HRQoL, mostly due to physical factors.
- dc.format.mimetype application/pdf
- dc.identifier.citation Comín-Colet J, Enjuanes C, González G, Torrens A, Cladellas M, Meroño O, et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Eur J Heart Fail. 2013 Oct;15(10):1164-72. DOI: 10.1093/eurjhf/hft083
- dc.identifier.doi http://dx.doi.org/10.1093/eurjhf/hft083
- dc.identifier.issn 1388-9842
- dc.identifier.uri http://hdl.handle.net/10230/69247
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Eur J Heart Fail. 2013 Oct;15(10):1164-72
- dc.rights © The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.keyword Anaemia
- dc.subject.keyword Health-related quality of life
- dc.subject.keyword Iron deficiency
- dc.title Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion