Global DNA methylation of ischemic stroke subtypes
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- dc.contributor.author Soriano Tarraga, Carolina
- dc.contributor.author Jiménez Conde, Jordi
- dc.contributor.author Giralt-Steinhauer, Eva
- dc.contributor.author Mola Caminal, Marina
- dc.contributor.author Ois Santiago, Angel Javier
- dc.contributor.author Rodríguez-Campello, Ana
- dc.contributor.author Cuadrado-Godia, Elisa
- dc.contributor.author Fernández-Cadenas, Israel
- dc.contributor.author Carrera, Caty
- dc.contributor.author Montaner, Joan
- dc.contributor.author Elosua Llanos, Roberto
- dc.contributor.author Roquer, Jaume
- dc.contributor.author The Spanish Stroke Genetics Consortium
- dc.date.accessioned 2025-01-14T08:23:05Z
- dc.date.available 2025-01-14T08:23:05Z
- dc.date.issued 2014
- dc.description.abstract Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. Epigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes and with modulation of the risk of various pathologies, such as cardiovascular disease and stroke. We analyzed 2 independent cohorts of IS patients. Global DNA methylation was measured by luminometric methylation assay (LUMA) of DNA blood samples. Univariate and multivariate regression analyses were used to assess the methylation differences between the 3 most common IS subtypes, large-artery atherosclerosis (LAA), small-artery disease (SAD), and cardio-aortic embolism (CE). A total of 485 IS patients from 2 independent hospital cohorts (n = 281 and n = 204) were included, distributed across 3 IS subtypes: LAA (78/281, 59/204), SAD (97/281, 53/204), and CE (106/281, 89/204). In univariate analyses, no statistical differences in LUMA levels were observed between the 3 etiologies in either cohort. Multivariate analysis, adjusted by age, sex, hyperlipidemia, and smoking habit, confirmed the lack of differences in methylation levels between the analyzed IS subtypes in both cohorts. Despite differences in pathogenesis, our results showed no global methylation differences between LAA, SAD, and CE subtypes of IS. Further work is required to establish whether the epigenetic mechanism of methylation might play a role in this complex disease.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Soriano-Tárraga C, Jiménez-Conde J, Giralt-Steinhauer E, Mola M, Ois Á, Rodríguez-Campello A, et al. Global DNA methylation of ischemic stroke subtypes. PLoS ONE. 2014 Apr 30;9(4):e96543. DOI: 10.1371/journal.pone.0096543
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0096543
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/69109
- dc.language.iso eng
- dc.publisher Public Library of Science (PLoS)
- dc.relation.ispartof PLoS ONE. 2014 Apr 30;9(4):e96543
- dc.rights © 2014 Soriano-Tárraga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.other ADNca
- dc.subject.other Isquèmiaca
- dc.subject.other Envellimentca
- dc.title Global DNA methylation of ischemic stroke subtypes
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion