The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study

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• dc.contributor.author Campbell, B.
• dc.contributor.author Raherison, C.
• dc.contributor.author Lodge, Caroline J.
• dc.contributor.author Lowe, Adrian J.
• dc.contributor.author Gislason, Thorarinn
• dc.contributor.author Heinrich, Joachim
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Gómez Real, Francisco
• dc.contributor.author Norbäck, Dan
• dc.contributor.author Matheson, Melanie C.
• dc.contributor.author Wjst, Matthias
• dc.contributor.author Dratva, Julia
• dc.contributor.author Marco, Roberto de
• dc.contributor.author Jarvis, Deborah
• dc.contributor.author Schlünssen, Vivi
• dc.contributor.author Janson, Christer
• dc.contributor.author Leynaert, Bénédicte
• dc.contributor.author Svanes, Cecilie
• dc.contributor.author Dharmage, Shyamali C.
• dc.date.accessioned 2019-04-02T10:01:50Z
• dc.date.available 2019-04-02T10:01:50Z
• dc.date.issued 2017
• dc.description.abstract Rationale: Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk. Objectives: To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood. Methods and measurements: The European Community Respiratory Health Survey II investigated ∼10 201 participants aged 26–54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A ‘biodiversity score’ was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed. Main results: As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation. Conclusions: This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment.
• dc.format.mimetype application/pdf
• dc.identifier.citation Campbell B, Raherison C, Lodge CJ, Lowe AJ, Gislason T, Heinrich J et al. The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study. Thorax. 2017;72(3):236-44. DOI: 10.1136/thoraxjnl-2015-208154
• dc.identifier.doi http://dx.doi.org/10.1136/thoraxjnl-2015-208154
• dc.identifier.issn 0040-6376
• dc.identifier.uri http://hdl.handle.net/10230/37021
• dc.language.iso eng
• dc.publisher BMJ Publishing Group
• dc.relation.ispartof Thorax. 2017;72(3):236-44
• dc.rights © BMJ Publishing Group http://dx.doi.org/10.1136/thoraxjnl-2015-208154
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Allergic lung disease
• dc.subject.keyword Asthma epidemiology
• dc.subject.keyword Respiratory measurement
• dc.title The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion