The pro-neurogenic effects of cannabidiol and its potential therapeutic implications in psychiatric disorders

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• dc.contributor.author Luján Pérez, Miguel Ángel, 1991-
• dc.contributor.author Valverde Granados, Olga
• dc.date.accessioned 2020-09-08T06:55:38Z
• dc.date.available 2020-09-08T06:55:38Z
• dc.date.issued 2020
• dc.description.abstract During the last decades, researchers have investigated the functional relevance of adult hippocampal neurogenesis in normal brain function as well as in the pathogenesis of diverse psychiatric conditions. Although the underlying mechanisms of newborn neuron differentiation and circuit integration have yet to be fully elucidated, considerable evidence suggests that the endocannabinoid system plays a pivotal role throughout the processes of adult neurogenesis. Thus, synthetic, and natural cannabinoid compounds targeting the endocannabinoid system have been utilized to modulate the proliferation and survival of neural progenitor cells and immature neurons. Cannabidiol (CBD), a constituent of the Cannabis Sativa plant, interacts with the endocannabinoid system by inhibiting fatty acid amide hydrolase (FAAH) activity (the rate-limiting enzyme for anandamide hydrolysis), allosterically modulating CB1 and CB2 receptors, and activating components of the "extended endocannabinoid system." Congruently, CBD has shown prominent pro-neurogenic effects, and, unlike Δ9-tetrahydrocannabinol, it has the advantage of being devoid of psychotomimetic effects. Here, we first review pre-clinical studies supporting the facilitating effects of CBD on adult hippocampal neurogenesis and available data disclosing cannabinoid mechanisms by which CBD can induce neural proliferation and differentiation. We then review the respective implications for its neuroprotective, anxiolytic, anti-depressant, and anti-reward actions. In conclusion, accumulating evidence reveals that, in rodents, adult neurogenesis is key to understand the behavioral manifestation of symptomatology related to different mental disorders. Hence, understanding how CBD promotes adult neurogenesis in rodents could shed light upon translational therapeutic strategies aimed to ameliorate psychiatric symptomatology dependent on hippocampal function in humans.
• dc.description.sponsorship This study was supported by the Ministerio de Economia y Competitividad (SAF2016-75966-R-FEDER) and Ministerio de Sanidad (Plan Nacional sobre Drogas: 2018/007). The Department of Experimental and Health Sciences (UPF) is a “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M).
• dc.format.mimetype application/pdf
• dc.identifier.citation Luján MÁ, Valverde O. The pro-neurogenic effects of cannabidiol and its potential therapeutic implications in psychiatric disorders. Front Behav Neurosci. 2020; 14:109. DOI: 10.3389/fnbeh.2020.00109
• dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2020.00109
• dc.identifier.issn 1662-5153
• dc.identifier.uri http://hdl.handle.net/10230/45263
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Behav Neurosci. 2020; 14:109
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R
• dc.rights © 2020 Luján and Valverde. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cannabidiol
• dc.subject.keyword Drug addiction
• dc.subject.keyword Endocannabinoid system
• dc.subject.keyword Hippocampus
• dc.subject.keyword Neurogenesis
• dc.subject.keyword Substance use disorder
• dc.title The pro-neurogenic effects of cannabidiol and its potential therapeutic implications in psychiatric disorders
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion