Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years after

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• dc.contributor.author Miret, Carme
• dc.contributor.author Orive, Miren
• dc.contributor.author Sala, Maria
• dc.contributor.author García Gutiérrez, Susana
• dc.contributor.author Sarasqueta, Cristina
• dc.contributor.author Legarreta, Maria José
• dc.contributor.author Redondo, Maximino
• dc.contributor.author Rivero, Amado
• dc.contributor.author Castells, Xavier
• dc.contributor.author Quintana, José María
• dc.contributor.author Garin Boronat, Olatz, 1979-
• dc.contributor.author Ferrer Forés, Maria Montserrat
• dc.contributor.author REDISSEC-CaMISS Group
• dc.date.accessioned 2023-03-03T07:40:13Z
• dc.date.available 2023-03-03T07:40:13Z
• dc.date.issued 2023
• dc.description.abstract Purpose: To obtain reference norms of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L, based on a population of Spanish non-metastatic breast cancer patients at diagnosis and 2 years after, according to relevant demographic and clinical characteristics. Methods: Multicentric prospective cohort study including consecutive women aged ≥ 18 years with a diagnosis of incident non-metastatic breast cancer from April 2013 to May 2015. Health-related quality of life (HRQoL) questionnaires were administered between diagnosis and beginning the therapy, and 2 years after. HRQoL differences according to age, comorbidity and stage were tested with ANOVA or Chi Square test and multivariate linear regression models. Results: 1276 patients were included, with a mean age of 58 years. Multivariate models of EORTC QLQ-C30 summary score and EQ-5D-5L index at diagnosis and at 2-year follow-up show the independent association of comorbidity and tumor stage with HRQoL. The standardized multivariate regression coefficient of EORTC QLQ-C30 summary score was lower (poorer HRQoL) for women with stage II and III than for those with stage 0 at diagnosis (- 0.11 and - 0.07, p < 0.05) and follow-up (- 0.15 and - 0.10, p < 0.01). The EQ-5D-5L index indicated poorer HRQoL for women with Charlson comorbidity index ≥ 2 than comorbidity 0 both at diagnosis (- 0.13, p < 0.001) and follow-up (- 0.18, p < 0.001). Therefore, we provided the reference norms at diagnosis and at the 2-year follow-up, stratified by age, comorbidity index, and tumor stage. Conclusion: These HRQoL reference norms can be useful to interpret the scores of women with non-metastatic breast cancer, comparing them with country-specific reference values for this population.
• dc.description.sponsorship The authors would like to acknowledge the support given by the Basque Government (ref IT1598-22) and by the Ministry of Education (ref PID2020-115738GB-100). Finally, the authors also thank Áurea Martín for her support in English editing, proofreading, and preparing this manuscript for submission.
• dc.format.mimetype application/pdf
• dc.identifier.citation Miret C, Orive M, Sala M, García-Gutiérrez S, Sarasqueta C, Legarreta MJ, Redondo M, Rivero A, Castells X, Quintana JM, Garin O, Ferrer M; REDISSEC-CaMISS Group. Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years after. Qual Life Res. 2023 Apr;32(4):989-1003. DOI: 10.1007/s11136-022-03327-4
• dc.identifier.doi http://dx.doi.org/10.1007/s11136-022-03327-4
• dc.identifier.issn 0962-9343
• dc.identifier.uri http://hdl.handle.net/10230/56014
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Quality of Life Research. 2023 Apr;32(4):989-1003
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-115738GB-100
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.title Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years after
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion