A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity

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• dc.contributor.author Levy, Shani
• dc.contributor.author Elek, Anamaria
• dc.contributor.author Grau Bové, Xavier
• dc.contributor.author Menéndez Bravo, Simón
• dc.contributor.author Iglesias, Marta
• dc.contributor.author Tanay, Amos
• dc.contributor.author Mass, Tali
• dc.contributor.author Sebé-Pedrós, Arnau
• dc.date.accessioned 2021-05-28T06:24:34Z
• dc.date.available 2021-05-28T06:24:34Z
• dc.date.issued 2021
• dc.description.abstract Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on Earth: coral reefs. Despite their ecological importance, little is known about the cell types and molecular pathways that underpin the biology of reef-building corals. Using single-cell RNA sequencing, we define over 40 cell types across the life cycle of Stylophora pistillata. We discover specialized immune cells, and we uncover the developmental gene expression dynamics of calcium-carbonate skeleton formation. By simultaneously measuring the transcriptomes of coral cells and the algae within them, we characterize the metabolic programs involved in symbiosis in both partners. We also trace the evolution of these coral cell specializations by phylogenetic integration of multiple cnidarian cell type atlases. Overall, this study reveals the molecular and cellular basis of stony coral biology.
• dc.description.sponsorship Research in the A.S.-P. group was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme grant agreement 851647, the Ministerio de Ciencia e Innovación, and the Centro de Excelencia Severo Ochoa (SEV-2016-0571 ). A.E. is supported by an FPI Severo Ochoa PhD fellowship from the Ministerio de Ciencia e Innovación. X.G.-B. is supported by a Juan de la Cierva fellowship ( FJC2018-036282-I ) from the Ministerio de Ciencia e Innovación . M.I. is supported by the European Union ’s H2020 research and innovation programme under Marie Sklodowska-Curie grant agreement 754422 . T.M. acknowledges that this project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme ( 755876). Research in the A.T. group was supported by the European Research Council (724824)
• dc.format.mimetype application/pdf
• dc.identifier.citation Levy S, Elek A, Grau-Bové X, Menéndez-Bravo S, Iglesias M, Tanay A et al. A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity. Cell. 2021;184(11):2973-87. DOI: 10.1016/j.cell.2021.04.005
• dc.identifier.doi http://dx.doi.org/10.1016/j.cell.2021.04.005
• dc.identifier.issn 0092-8674
• dc.identifier.uri http://hdl.handle.net/10230/47676
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cell. 2021;184(11):2973-87.
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/851647
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/754422
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/755876
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724824
• dc.rights © 2021 Shani Levy et al. Published by Elsevier Inc. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Genètica
• dc.subject.other Coralls
• dc.title A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion