Plasmodium vivax malaria viewed through the lens of an eradicated european strain

van Dorp, Lucy; Gelabert Xirinachs, Pere, 1991-; Rieux, Adrien; de Manuel, Marc; de Dios, Toni; Gopalakrishnan, Shyam; Carøe, Christian; Sandoval Velasco, Marcela; Fregel, Rosa; Olalde Marquínez, Íñigo, 1987-; Escosa, Raül; Aranda, Carles; Huijben, Silvie; Mueller, Ivo; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Gilbert, M Thomas; Lalueza Fox, Carles, 1965-

Plasmodium vivax malaria viewed through the lens of an eradicated european strain

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dc.contributor.author van Dorp, Lucy
dc.contributor.author Gelabert Xirinachs, Pere, 1991-
dc.contributor.author Rieux, Adrien
dc.contributor.author de Manuel, Marc
dc.contributor.author de Dios, Toni
dc.contributor.author Gopalakrishnan, Shyam
dc.contributor.author Carøe, Christian
dc.contributor.author Sandoval Velasco, Marcela
dc.contributor.author Fregel, Rosa
dc.contributor.author Olalde Marquínez, Íñigo, 1987-
dc.contributor.author Escosa, Raül
dc.contributor.author Aranda, Carles
dc.contributor.author Huijben, Silvie
dc.contributor.author Mueller, Ivo
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Balloux, François
dc.contributor.author Gilbert, M Thomas
dc.contributor.author Lalueza Fox, Carles, 1965-
dc.date.accessioned 2020-04-20T07:35:16Z
dc.date.available 2020-04-20T07:35:16Z
dc.date.issued 2020
dc.description.abstract The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonization of the Americas. In addition, we found that some known variants for resistance to antimalarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.
dc.description.sponsorship This research was supported by a grant from Obra Social “La Caixa,” Secretaria d’Universitats i Recerca Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880), Secretaria d’Universitats i Recerca (GRC2017-SGR880), and by FEDER-Ministry of Science, Innovation and Universities (MCIU) (PGC2018-095931-B-100) to C.L.-F. and an European Research Council (ERC) Consolidator Grant (681396-Extinction Genomics) to M.T.P.G. L.v.D., and F.B. acknowledge financial support from the Newton Fund UK–China NSFC initiative (grant MR/P007597/1) and the Biotechnology and Biological Sciences Research Council (BBSRC) (equipment grant BB/R01356X/1). Plasmodium vivax genomes are deposited with ENA BioProject ID PRJEB30878. We also thank the Danish National High Throughput Sequencing Centre for help in sequencing.
dc.format.mimetype application/pdf
dc.identifier.citation van Dorp L, Gelabert P, Rieux A, de Manuel M, de-Dios T, Gopalakrishnan S, Carøe C, Sandoval-Velasco M, Fregel R, Olalde I, Escosa R, Aranda C, Huijben S, Mueller I, Marquès-Bonet T, Balloux F, Gilbert MTP, Lalueza-Fox C. Plasmodium vivax malaria viewed through the lens of an eradicated european strain. Mol Biol Evol. 2020; 37(3):773-85. DOI: 10.1093/molbev/msz264
dc.identifier.doi http://dx.doi.org/10.1093/molbev/msz264
dc.identifier.issn 0737-4038
dc.identifier.uri http://hdl.handle.net/10230/44277
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Mol Biol Evol. 2020; 37(3):773-85
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/681396
dc.rights © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keyword Plasmodium vivax
dc.subject.keyword Ancient DNA
dc.subject.keyword Malaria
dc.subject.keyword Phylogenetics
dc.subject.keyword Population genetics
dc.title Plasmodium vivax malaria viewed through the lens of an eradicated european strain
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
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