Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA)

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Oncina-Cánovas, Alejandro
  • dc.contributor.author Vioque, Jesus
  • dc.contributor.author Riutort-Mayol, Gabriel
  • dc.contributor.author Soler Blasco, Raquel
  • dc.contributor.author Irizar, Amaia
  • dc.contributor.author Barroeta, Ziortza
  • dc.contributor.author Fernández-Somoano, Ana
  • dc.contributor.author Tardón, Adonina
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Carey, Manus
  • dc.contributor.author Meharg, Caroline
  • dc.contributor.author Ralphs, Kathryn
  • dc.contributor.author McCreanor, Coalain
  • dc.contributor.author Meharg, Andrew A.
  • dc.contributor.author Signes-Pastor, Antonio J.
  • dc.date.accessioned 2024-07-02T06:22:30Z
  • dc.date.available 2024-07-02T06:22:30Z
  • dc.date.issued 2024
  • dc.description.abstract Dietary patterns provide a comprehensive assessment of food consumption, including essential nutrients and potential exposure to environmental contaminants. While pro-vegetarian (PVG) dietary patterns have shown health benefits in adults, their effects on children are less well studied. This study aims to explore the association between children's adherence to the most common PVG dietary patterns and their exposure to metals, assessed through urine concentration. In our study, we included a population of 723 children aged 4-5-years from the INfancia y Medio Ambiente (INMA) cohort in Spain. We calculated three predefined PVG dietary patterns, namely general (gPVG), healthful (hPVG), and unhealthful (uPVG), using dietary information collected through a validated Food Frequency Questionnaire. Urinary concentrations of various essential and heavy metals (Co, Cu, Zn, Se, Mo, Pb, and Cd) were measured using mass spectrometry. Additionally, urinary arsenic speciation, including arsenobetaine (AsB), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), and inorganic arsenic (iAs), was measured. The sum of urinary MMA and iAs was used to assess iAs exposure. We estimated primary (PMI) and secondary iAs methylation (SMI) indices. To explore the association between PVG dietary patterns in quintiles and metal exposure, we utilized multiple-adjusted linear regression models and the quantile g-computation approach. Compared with the lowest quintile, participants in the highest quintile of gPVG showed a 22.7% lower urinary Co (95% confidence interval (CI): -38.7; -1.98) and a 12.6% lower Se (95%CI: -22.9; -1.00) concentrations. Second quintile of adherence to hPVG was associated with a 51.7% lower urinary iAs + MMA concentrations (95%CI: -74.3; -8.61). Second quintile of adherence to an uPVG was associated with a 13.6% lower Se levels (95%CI: -22.9; -2.95) while the third quintile to this pattern was associated with 17.5% lower Mo concentrations (95%CI: -29.5; -2.95). The fourth quintile of adherence to gPVG was associated with a 68.5% higher PMI and a 53.7% lower SMI. Our study showed that adherence to a gPVG dietary pattern in childhood may modestly reduce the intakes of some essential metals such as Co and Se. Further investigations are warranted to explore any potential health implications.
  • dc.description.sponsorship This study was funded by CIDEGENT/2020/050 and grants from Spanish Institute of Health Carlos III, ISCIII-FEDER: PI07/0314, PI11/01007, PI16/1288, PI19/1338, PI04/2018, PI09/02311, PI13/02429, PI16/1288, PI18/00909, PIS06/0867, PI09/00090, PI13/02187, PI04/1436; PI08/1151, PI18/01142, PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687 and PI17/00663. FIS-FSEE: 17/00260, Red INMA G03/176; CB06/02/0041 incl. FEDER funds. Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5–1). Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430). Ministry of Universities (Margarita Salas Grant MS21-133). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. Fundación Cajastur, and Universidad de Oviedo. Miguel Servet fellowship (CP16/00128, CP11/00178, CP15/00025, CPII16/00051, CP18/00018) and Sara Borrell fellowship (CD21/00186) funded by Instituto de Salud Carlos III and cofounded by European Social Fund “Investing in your future.” CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089, 2015111065 and 2018111086), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221 and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). Generalitat Valenciana: FISABIO (UGP 15–230, UGP-15-244, and UGP-15-249), and Alicia Koplowitz Foundation 2017.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Oncina-Cánovas A, Vioque J, Riutort-Mayol G, Soler-Blasco R, Irizar A, Barroeta Z, et al. Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA). Int J Hyg Environ Health. 2024 Apr;257:114344. DOI: 10.1016/j.ijheh.2024.114344
  • dc.identifier.doi http://dx.doi.org/10.1016/j.ijheh.2024.114344
  • dc.identifier.issn 1438-4639
  • dc.identifier.uri http://hdl.handle.net/10230/60629
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Int J Hyg Environ Health. 2024 Apr;257:114344
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights © 2024 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Arsenic speciation
  • dc.subject.keyword Childhood
  • dc.subject.keyword Metal exposure
  • dc.subject.keyword Pro-vegetarian
  • dc.title Pro-vegetarian dietary patterns and essential and heavy metal exposure in children of 4-5-years from the INfancia y medio Ambiente cohort (INMA)
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)