Comparative genomics of emerging pathogens in the Candida glabrata clade

Gabaldón Estevan, Juan Antonio, 1973-; Martin, Tiphaine; Marcet Houben, Marina; Durrens, Pascal; Bolotin Fukuhara, Monique; Lespinet, Olivier; Arnaise, Sylvie; Boisnard, Stéphanie; Aguileta, Gabriela; Atanasova, Ralitsa; Bouchier, Christiane; Couloux, Arnaud; Creno, Sophie; Almeida Cruz, José; Devillers, Hugo; Enache-Angoulvant, Aadela; Guitard, Juliette; Jaouen, Laure; Ma, Laurence; Marck, Christian; Neuvéglise, Cécile; Pelletier, Eric; Pinard, Amélie; Poulain, Julie; Recoquillay, Julien; Westhof, Eric; Wincker, Patrick; Dujon, Bernard; Hennequin, Christophe; Fairhead, Cécile

Comparative genomics of emerging pathogens in the Candida glabrata clade

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dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
dc.contributor.author Martin, Tiphaineca
dc.contributor.author Marcet Houben, Marinaca
dc.contributor.author Durrens, Pascalca
dc.contributor.author Bolotin Fukuhara, Moniqueca
dc.contributor.author Lespinet, Olivierca
dc.contributor.author Arnaise, Sylvieca
dc.contributor.author Boisnard, Stéphanieca
dc.contributor.author Aguileta, Gabrielaca
dc.contributor.author Atanasova, Ralitsaca
dc.contributor.author Bouchier, Christianeca
dc.contributor.author Couloux, Arnaudca
dc.contributor.author Creno, Sophieca
dc.contributor.author Almeida Cruz, Joséca
dc.contributor.author Devillers, Hugoca
dc.contributor.author Enache-Angoulvant, Aadelaca
dc.contributor.author Guitard, Julietteca
dc.contributor.author Jaouen, Laureca
dc.contributor.author Ma, Laurenceca
dc.contributor.author Marck, Christianca
dc.contributor.author Neuvéglise, Cécileca
dc.contributor.author Pelletier, Ericca
dc.contributor.author Pinard, Amélieca
dc.contributor.author Poulain, Julieca
dc.contributor.author Recoquillay, Julienca
dc.contributor.author Westhof, Ericca
dc.contributor.author Wincker, Patrickca
dc.contributor.author Dujon, Bernardca
dc.contributor.author Hennequin, Christopheca
dc.contributor.author Fairhead, Cécileca
dc.date.accessioned 2014-05-14T07:34:15Z
dc.date.available 2014-05-14T07:34:15Z
dc.date.issued 2013ca
dc.description.abstract BACKGROUND: Candida glabrata follows C. albicans as the second or third most prevalent cause of candidemia worldwide. These two pathogenic yeasts are distantly related, C. glabrata being part of the Nakaseomyces, a group more closely related to Saccharomyces cerevisiae. Although C. glabrata was thought to be the only pathogenic Nakaseomyces, two new pathogens have recently been described within this group: C. nivariensis and C. bracarensis. To gain insight into the genomic changes underlying the emergence of virulence, we sequenced the genomes of these two, and three other non-pathogenic Nakaseomyces, and compared them to other sequenced yeasts. RESULTS: Our results indicate that the two new pathogens are more closely related to the non-pathogenic N. delphensis than to C. glabrata. We uncover duplications and accelerated evolution that specifically affected genes in the lineage preceding the group containing N. delphensis and the three pathogens, which may provide clues to the higher propensity of this group to infect humans. Finally, the number of Epa-like adhesins is specifically enriched in the pathogens, particularly in C. glabrata. CONCLUSIONS: Remarkably, some features thought to be the result of adaptation of C. glabrata to a pathogenic lifestyle, are present throughout the Nakaseomyces, indicating these are rather ancient adaptations to other environments. Phylogeny suggests that human pathogenesis evolved several times, independently within the clade. The expansion of the EPA gene family in pathogens establishes an evolutionary link between adhesion and virulence phenotypes. Our analyses thus shed light onto the relationships between virulence and the recent genomic changes that occurred within the Nakaseomyces.
dc.description.sponsorship This work was supported by funding from the European Research Council/nunder the European Union’s Seventh Framework Programme (FP/2007- 2013)/ERC Grant Agreement n.310325, a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and by a grant from the Spanish Ministry of Economy and Competitiveness (BIO2012-37161). CF’s research is/nfunded in part by an “Attractivité” grant from the University Paris Sud. GA is/na recipient of a Marie Curie grant (FP7-PEOPLE-2010-IEF-No.274223). SB, HD and RA are recipients of, respectively, a shared post-doctoral grant and a Ph. D. grant, from the Région Ile-de-France’s DIM Malinf program. JAC was supported by the Ph.D. Program in Computational Biology of the Instituto Gulbenkian de Ciência, Portugal (sponsored by Fundação Calouste Gulbenkian, Siemens SA, and Fundação para a Ciência e Tecnologia; SFRH/BD/33528/2008)
dc.format.mimetype application/pdfca
dc.identifier.citation Gabaldón T, Martin T, Marcet-Houben M, Durrens P, Bolotin-Fukuhara M, Lespinet O et al. Comparative genomics of emerging pathogens in the Candida glabrata clade. BMC Genomics. 2013;14:623. DOI: 10.1186/1471-2164-14-623ca
dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-14-623
dc.identifier.issn 1471-2164ca
dc.identifier.uri http://hdl.handle.net/10230/22483
dc.language.iso engca
dc.publisher BioMed Centralca
dc.relation.ispartof BMC Genomics. 2013;14:623
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325ca
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/274223
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/2.0/
dc.subject.other Genòmica
dc.subject.other Llevats -- Genètica
dc.subject.other Càndida
dc.title Comparative genomics of emerging pathogens in the Candida glabrata cladeca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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