Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Guegan, Thomas, 1983-ca
- dc.contributor.author Cebrià i Costa, Joan Pau, 1989-ca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Martín Sánchez, Miquel, 1971-ca
- dc.date.accessioned 2017-04-24T10:03:59Z
- dc.date.issued 2016
- dc.description.abstract Changes in structural plasticity produced by the chronic exposure to drugs of abuse, such as alterations in dendritic spine densities, participate in the development of maladaptive learning processes leading to drug addiction. Understanding the neurobiological mechanisms involved in these aberrant changes is crucial to clarify the neurobiological substrate of addiction. Drug-induced locomotor sensitization has been widely accepted as a useful animal model to study these mechanisms related to drug addiction. We have evaluated the changes in structural plasticity in the mesocorticolimbic system involved in morphine-induced locomotor sensitization. The role of the cannabinoid receptor type 1 (CB1-R) in these neuroplastic alterations has also been studied using CB1-R-deficient (CB1-R KO) mice. Structural plasticity changes promoted by morphine are a highly dynamic phenomenon that evolves during the entire time course of the behavioral sensitization in wild-type (WT) animals. The different phases of the sensitization process were related to specific changes in connectivity between neurons revealed by modifications in dendritic spines in specific areas of the mesocorticolimbic system. Moreover, the lack of morphine-induced locomotor sensitization in CB1-R KO mice was accompanied by abnormal alterations in structural plasticity in the same mesocorticolimbic areas. These specific structural plasticity changes mediated by CB1-R activity seem necessary for the normal progression of morphine-induced locomotor sensitization and could play a critical role in the addictive process.
- dc.description.sponsorship This work was supported by European Commission-FP7 (#HEALTH-F2-2013-602891), RETICS-Instituto de Salud Carlos III (#RD12/0028/0023), MICINN-Ministerio de Ciencia e Innovación (#SAF2011-29864) and AGAUR-Generalitat de Catalunya (#2009SGR00731 and #2014-SGR-1547). FEDER co-funding is also acknowledged
- dc.format.mimetype application/pdfca
- dc.identifier.citation Guegan T, Cebrià JP, Maldonado R, Martin M. Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity. Addict Biol. 2016 Nov;21(6):1113-26. DOI: 10.1111/adb.12281
- dc.identifier.doi http://dx.doi.org/10.1111/adb.12281
- dc.identifier.issn 1355-6215
- dc.identifier.uri http://hdl.handle.net/10230/30871
- dc.language.iso eng
- dc.publisher Wileyca
- dc.relation.ispartof Addiction Biology. 2016 Nov;21(6):1113-26
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/602891
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
- dc.rights This is the pre-peer reviewed version of the following article: Guegan T, Cebrià JP, Maldonado R, Martin M. Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity. Addict Biol. 2016 Nov; 21(6): 1113-1126, which has been published in final form at http://dx.doi.org/10.1111/adb.12281. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Drogoaddicció
- dc.subject.other Cannabinoides -- Receptors
- dc.title Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activityca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion