Skin microdialysis: methods, applications and future opportunities-an EAACI position paper

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• dc.contributor.author Baumann, Katrine Y.
• dc.contributor.author Church, Martin K.
• dc.contributor.author Clough, Geraldine F.
• dc.contributor.author Quist, Sven Roy
• dc.contributor.author Schmelz, Martin
• dc.contributor.author Skov, Per Stahl
• dc.contributor.author Anderson, Christopher D.
• dc.contributor.author Tannert, Line Kring
• dc.contributor.author Giménez Arnau, Anna Maria
• dc.contributor.author Frischbutter, Stefan
• dc.contributor.author Schefel, Jörg
• dc.contributor.author Maurer, Marcus
• dc.date.accessioned 2019-11-27T08:32:42Z
• dc.date.available 2019-11-27T08:32:42Z
• dc.date.issued 2019
• dc.description.abstract Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo.
• dc.format.mimetype application/pdf
• dc.identifier.citation Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS et al. Skin microdialysis: methods, applications and future opportunities-an EAACI position paper. Clin Transl Allergy. 2019 Apr 10;9:24. DOI: 10.1186/s13601-019-0262-y
• dc.identifier.doi http://dx.doi.org/10.1186/s13601-019-0262-y
• dc.identifier.issn 2045-7022
• dc.identifier.uri http://hdl.handle.net/10230/42997
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Clinical and Translational Allergy. 2019 Apr 10;9:24
• dc.rights Copyright © The Author(s) 2019. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cutaneous
• dc.subject.keyword Dermal
• dc.subject.keyword Inflammation
• dc.subject.keyword Interstitial
• dc.subject.keyword Microdialysis
• dc.title Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion