Altered gesture imitation and brain anatomy in adult prader-willi syndrome patients

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• dc.contributor.author Caixàs, Assumpta
• dc.contributor.author Blanco Hinojo, Laura, 1981-
• dc.contributor.author Pujol Martí, Jesús, 1981-
• dc.contributor.author Deus, Joan
• dc.contributor.author Giménez Palop, Olga
• dc.contributor.author Torrents-Rodas, David
• dc.contributor.author Coronas, Ramon
• dc.contributor.author Novell, Ramon
• dc.contributor.author Esteba-Castillo, Susanna
• dc.date.accessioned 2022-06-27T06:36:42Z
• dc.date.available 2022-06-27T06:36:42Z
• dc.date.issued 2021
• dc.description.abstract Objective: To explore motor praxis in adults with Prader-Willi syndrome (PWS) in comparison with a control group of people with intellectual disability (ID) and to examine the relationship with brain structural measurements. Method: Thirty adult participants with PWS and 132 with ID of nongenetic etiology (matched by age, sex, and ID level) were assessed using a comprehensive evaluation of the praxis function, which included pantomime of tool use, imitation of meaningful and meaningless gestures, motor sequencing, and constructional praxis. Results: Results support specific praxis difficulties in PWS, with worse performance in the imitation of motor actions and better performance in constructional praxis than ID peers. Compared with both control groups, PWS showed increased gray matter volume in sensorimotor and subcortical regions. However, we found no obvious association between these alterations and praxis performance. Instead, praxis scores correlated with regional volume measures in distributed apparently normal brain areas. Conclusions: Our findings are consistent in showing significant impairment in gesture imitation abilities in PWS and, otherwise, further indicate that the visuospatial praxis domain is relatively preserved. Praxis disability in PWS was not associated with a specific, focal alteration of brain anatomy. Altered imitation gestures could, therefore, be a consequence of widespread brain dysfunction. However, the specific contribution of key brain structures (e.g., areas containing mirror neurons) should be more finely tested in future research.
• dc.format.mimetype application/pdf
• dc.identifier.citation Caixàs A, Blanco-Hinojo L, Pujol J, Deus J, Giménez-Palop O, Torrents-Rodas D, Altered gesture imitation and brain anatomy in adult prader-willi syndrome patients. J Int Neuropsychol Soc. 2021 Nov; 27(10): 1024-36. DOI: 10.1017/S1355617721000060
• dc.identifier.doi http://dx.doi.org/10.1017/S1355617721000060
• dc.identifier.issn 1355-6177
• dc.identifier.uri http://hdl.handle.net/10230/53600
• dc.language.iso eng
• dc.publisher Cambridge University Press
• dc.rights © Cambridge University Press. The published version of the article: Caixàs A, Blanco-Hinojo L, Pujol J, Deus J, Giménez-Palop O, Torrents-Rodas D, Altered gesture imitation and brain anatomy in adult prader-willi syndrome patients. J Int Neuropsychol Soc. 2021 Nov; 27(10): 1024-36, is available at https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/abs/altered-gesture-imitation-and-brain-anatomy-in-adult-praderwilli-syndrome-patients/0F22639DDDA658456C65AC3F71822436.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Brain anatomy
• dc.subject.keyword Gesture imitation
• dc.subject.keyword Magnetic resonance imaging
• dc.subject.keyword Prader–Willi syndrome
• dc.subject.keyword Praxis
• dc.subject.keyword Voxel-based morphometry
• dc.title Altered gesture imitation and brain anatomy in adult prader-willi syndrome patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion