Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents

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• dc.contributor.author Güil Oumrait, Núria
• dc.contributor.author Cano-Sancho, German
• dc.contributor.author Montazeri, Parisa, 1988-
• dc.contributor.author Stratakis, Nikos
• dc.contributor.author Warembourg, Charline
• dc.contributor.author Lopez-Espinosa, Maria-José
• dc.contributor.author Vioque, Jesus
• dc.contributor.author Santa Marina, Loreto
• dc.contributor.author Jimeno-Romero, Alba
• dc.contributor.author Ventura Alemany, Rosa
• dc.contributor.author Monfort Mercader, Núria, 1983-
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Casas Sanahuja, Maribel
• dc.date.accessioned 2022-11-24T07:01:16Z
• dc.date.available 2022-11-24T07:01:16Z
• dc.date.issued 2022
• dc.description.abstract Background: Pregnant women are simultaneously exposed to several non-persistent endocrine-disrupting chemicals, which may influence the risk of childhood obesity and cardiovascular diseases later in life. Previous prospective studies have mostly examined single-chemical effects, with inconsistent findings. We assessed the association between prenatal exposure to phthalates and phenols, individually and as a mixture, and body mass index (BMI) and blood pressure (BP) in preadolescents. Methods: We used data from the Spanish INMA birth cohort study (n = 1,015), where the 1st and 3rd- trimester maternal urinary concentrations of eight phthalate metabolites and six phenols were quantified. At 11 years of age, we calculated BMI z-scores and measured systolic and diastolic BP. We estimated individual chemical effects with linear mixed models and joint effects of the chemical mixture with hierarchical Bayesian kernel machine regression (BKMR). Analyses were stratified by sex and by puberty status. Results: In single-exposure models, benzophenone-3 (BP3) was nonmonotonically associated with higher BMI z-score (e.g. Quartile (Q) 3: β = 0.23 [95% CI = 0.03, 0.44] vs Q1) and higher diastolic BP (Q2: β = 1.27 [0.00, 2.53] mmHg vs Q1). Methyl paraben (MEPA) was associated with lower systolic BP (Q4: β = -1.67 [-3.31, -0.04] mmHg vs Q1). No consistent associations were observed for the other compounds. Results from the BKMR confirmed the single-exposure results and showed similar patterns of associations, with BP3 having the highest importance in the mixture models, especially among preadolescents who reached puberty status. No overall mixture effect was found, except for a tendency of higher BMI z-score and lower systolic BP in girls. Conclusions: Prenatal exposure to UV-filter BP3 may be associated with higher BMI and diastolic BP during preadolescence, but there is little evidence for an overall phthalate and phenol mixture effect.
• dc.description.sponsorship We thank all study participants for their generous collaboration. INMA-Sabadell: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR 2009 SGR 501, Fundació La marató de TV3 (090430), EU Commission (261357, H2020 No 874583, the ATHLETE project, and No 825712, the OBERON project). Maribel Casas holds a Miguel Servet fellowship (MS16/00128) funded by Instituto de Salud Carlos III and co-funded by European Social Fund “Investing in your future”. We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. INMA-Gipuzkoa: This study was funded by grants from Instituto de Salud Carlos III (FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2015111065), and the Provincial Government of Gipuzkoa (DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). INMA-Valencia: This study was funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: ISCIII (G03/176; FIS-FEDER: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-FEDER MS11/00178, MS15/00025, and MSII16/00051), Generalitat Valenciana (AICO/2021/182, and FISABIO: UGP 15-230, UGP-15-244, and UGP-15-249), and Alicia Koplowitz Foundation 2017.
• dc.format.mimetype application/pdf
• dc.identifier.citation Güil-Oumrait N, Cano-Sancho G, Montazeri P, Stratakis N, Warembourg C, Lopez-Espinosa MJ, Vioque J, Santa-Marina L, Jimeno-Romero A, Ventura R, Monfort N, Vrijheid M, Casas M. Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents. Environ Int. 2022 Nov;169:107527. DOI: 10.1016/j.envint.2022.107527
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2022.107527
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/54990
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2022 Nov;169:107527
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825712
• dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Benzophenone-3
• dc.subject.keyword Blood pressure (BP)
• dc.subject.keyword Body mass index (BMI)
• dc.subject.keyword Parabens
• dc.subject.keyword Phenols
• dc.subject.keyword Phthalates
• dc.title Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion