Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells
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- dc.contributor.author Muñoz Cánoves, Pura, 1962-
- dc.contributor.author Neves, Joana
- dc.contributor.author Sousa-Victor, Pedro
- dc.date.accessioned 2023-04-25T06:14:23Z
- dc.date.available 2023-04-25T06:14:23Z
- dc.date.issued 2019
- dc.description.abstract Aging is characterized by the progressive dysfunction of most tissues and organs, which has been linked to the regenerative decline of their resident stem cells over time. Skeletal muscle provides a stark example of this decline. Its stem cells, also called satellite cells, sustain muscle regeneration throughout life, but at advanced age they fail for largely undefined reasons. Here, we discuss current understanding of the molecular processes regulating satellite cell maintenance throughout life and how age-related failure of these processes contributes to muscle aging. We also highlight the emerging field of rejuvenating biology to restore features of youthfulness in satellite cells, with the ultimate goal of slowing down or reversing the age-related decline in muscle regeneration.
- dc.description.sponsorship Work in the authors’ laboratories has been supported by the following funding sources: The Spanish Ministry of Science, Innovation and Universities, Spain [grants RTI2018-096068-B-I00 and SAF 2015-70270-REDT, a María de Maeztu Unit of Excellence award to UPF (MDM-2014-0370), and a Severo Ochoa Center of Excellence award to the CNIC (SEV-2015-0505)], ERC-2016-AdG-741966, La Caixa-HEALTH (HR17-00040), MDA, UPGRADE-H2020-825825, AFM and DPP-E to PMC; JN and PSV acknowledge support from iMM start-up funding and ‘la Caixa’ Foundation for the Junior Leader Fellowship for PSV (LCF/BQ/PI19/11690006).
- dc.format.mimetype application/pdf
- dc.identifier.citation Muñoz-Cánoves P, Neves J, Sousa-Victor P. Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells. FEBS J. 2020; 287(3):406-16. DOI: 10.1111/febs.15182
- dc.identifier.doi http://dx.doi.org/10.1111/febs.15182
- dc.identifier.issn 1742-464X
- dc.identifier.uri http://hdl.handle.net/10230/56556
- dc.language.iso eng
- dc.publisher Wiley-Blackwell
- dc.relation.ispartof FEBS J. 2020; 287(3):406-16
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015‐70270‐REDT
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/741966
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825825
- dc.rights This is the pre-peer reviewed version of the following article: Muñoz-Cánoves P, Neves J, Sousa-Victor P. Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells. FEBS J. 2020; 287(3):406-16. DOI: 10.1111/febs.15182, which has been published in final form at http://dx.doi.org/10.1111/febs.15182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Aging
- dc.subject.keyword Regeneration
- dc.subject.keyword Rejuvenation
- dc.subject.keyword Sarcopenia
- dc.subject.keyword Satellite cell
- dc.subject.keyword Skeletal muscle
- dc.subject.keyword Stem cell
- dc.subject.keyword Tissue repair
- dc.title Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion