Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice

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• dc.contributor.author Martin Casals, Miquel
• dc.contributor.author Gutiérrez Martos, Miriam, 1989-
• dc.contributor.author Cabrera Ortega, Roberto
• dc.contributor.author Langohr, Klaus
• dc.contributor.author Maldonado, Rafael, 1961-
• dc.contributor.author Farré Albaladejo, Magí
• dc.contributor.author Torre Fornell, Rafael de la
• dc.date.accessioned 2021-05-11T06:59:48Z
• dc.date.available 2021-05-11T06:59:48Z
• dc.date.issued 2021
• dc.description.abstract Rationale: Cocaine addiction is a chronic relapsing disorder that lacks of an effective treatment. Isoflavones are a family of compounds present in different plants and vegetables like soybeans that share a common chemical structure. Previous studies have described that synthetic derivatives from the natural isoflavone daidzin can modulate cocaine addiction, by a mechanism suggested to involve aldehyde-dehydrogenase (ALDH) activities. Objectives: Based on these previous studies, we investigated the effects of three natural isoflavones, daidzin, daidzein, and genistein, on the modulation of the cocaine reinforcing effects and on cue-induced reinstatement in an operant mouse model of cocaine self-administration. Results: Chronic treatment with daidzein or genistein decreased operant responding to obtain cocaine intravenous infusions. On the other hand, daidzein and daidzin, but not genistein, were effective in decreasing cue-induced cocaine reinstatement. Complementary studies revealed that daidzein effects on cocaine reinforcement were mediated through a mechanism that involved dopamine type-2/3 receptors (DA-D2/3) activities. Conclusions: Our results suggest that these natural compounds alone or in combination can be a potential therapeutic approach for cocaine addiction. Further clinical studies are required in order to ascertain their potential therapeutic use.
• dc.format.mimetype application/pdf
• dc.identifier.citation Martin M, Gutiérrez-Martos M, Cabrera R, Langohr K, Maldonado R, Farre M, de la Torre R. Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice. Psychopharmacology (Berl). 2021;238(7):1923-36. DOI: 10.1007/s00213-021-05820-z
• dc.identifier.doi http://dx.doi.org/10.1007/s00213-021-05820-z
• dc.identifier.issn 0033-3158
• dc.identifier.uri http://hdl.handle.net/10230/47384
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Psychopharmacology (Berl). 2021;238(7):1923-36
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cocaine
• dc.subject.keyword Daidzein
• dc.subject.keyword Daidzin
• dc.subject.keyword Dopamine receptors
• dc.subject.keyword Genistein
• dc.subject.keyword Isoflavones
• dc.subject.keyword Reinforcing
• dc.subject.keyword Reinstatement
• dc.subject.keyword Self-administration
• dc.title Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion