Urinary arsenic speciation in children and pregnant women from Spain
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- dc.contributor.author Signes-Pastor, Antonio J.
- dc.contributor.author Carey, Manus
- dc.contributor.author Vioque, Jesus
- dc.contributor.author Navarrete-Muñoz, Eva-María
- dc.contributor.author Rodríguez Dehli, Cristina
- dc.contributor.author Tardón, Adonina
- dc.contributor.author Begoña Zubero, Miren
- dc.contributor.author Santa Marina, Loreto
- dc.contributor.author Vrijheid, Martine
- dc.contributor.author Casas Sanahuja, Maribel
- dc.contributor.author Llop, Sabrina
- dc.contributor.author Gonzalez-Palacios, Sandra
- dc.contributor.author Meharg, Andrew A.
- dc.date.accessioned 2025-01-14T08:15:05Z
- dc.date.available 2025-01-14T08:15:05Z
- dc.date.issued 2017
- dc.description.abstract Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 μg/l (arsenobetaine—AsB), 3.97 μg/l (dimethylarsinic acid—DMA), 0.44 μg/l (monomethylarsonic acid—MMA) and 0.35 μg/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman’s correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.en
- dc.description.sponsorship This work was funded by a Marie Curie Intra-European Fellowship within the 7th European Community Framework Programme (RICENIC project—PIEF-GA-2013-622096) and the INMA project (http://www.proyectoinma.org/), which is supported by grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1436, 04/1931, 04/2018, 05/1079, 05/1052, 06/0867, 06/1213, 07/0314, 08/1151, 09/00090, 09/02311, 09/02647, 11/0178, 11/01007, 11/02591, 11/02038, 13/1944, 13/2032, 13/02187, 13/02429, 14/0891, 14/1687 and Miguel Servet-FEDER CP15/00025), CIBERESP and the Conselleria de Sanitat, Generalitat Valenciana; Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430); Obra Social Cajastur/Fundación Liberbank and UNIVERSIDAD DE OVIEDO; Department of Health of the Basque Government (2005111093, 2009111069 and 2013111089), and the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001); Convenios anuales con los ayuntamientos de la zona del estudio (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain).en
- dc.format.mimetype application/pdf
- dc.identifier.citation Signes-Pastor AJ, Carey M, Vioque J, Navarrete-Muñoz EM, Rodríguez-Dehli C, Tardón A, et al. Urinary arsenic speciation in children and pregnant women from Spain. Expo Health. 2017 Jun;9(2):105-11. DOI: 10.1007/s12403-016-0225-7
- dc.identifier.doi http://dx.doi.org/10.1007/s12403-016-0225-7
- dc.identifier.issn 2451-9685
- dc.identifier.uri http://hdl.handle.net/10230/69099
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof Exposure and Health . 2017 Jun;9(2):105-11
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
- dc.rights This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Arsenic speciationen
- dc.subject.keyword Childrenen
- dc.subject.keyword Pregnant womenen
- dc.subject.keyword Biomarkeren
- dc.subject.keyword Urinary metabolitesen
- dc.subject.keyword Inorganic arsenicen
- dc.title Urinary arsenic speciation in children and pregnant women from Spain
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion