Urinary arsenic speciation in children and pregnant women from Spain

Signes-Pastor, Antonio J.; Carey, Manus; Vioque, Jesus; Navarrete-Muñoz, Eva-María; Rodríguez Dehli, Cristina; Tardón, Adonina; Begoña Zubero, Miren; Santa Marina, Loreto; Vrijheid, Martine; Casas Sanahuja, Maribel; Llop, Sabrina; Gonzalez-Palacios, Sandra; Meharg, Andrew A.

Urinary arsenic speciation in children and pregnant women from Spain

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dc.contributor.author Signes-Pastor, Antonio J.
dc.contributor.author Carey, Manus
dc.contributor.author Vioque, Jesus
dc.contributor.author Navarrete-Muñoz, Eva-María
dc.contributor.author Rodríguez Dehli, Cristina
dc.contributor.author Tardón, Adonina
dc.contributor.author Begoña Zubero, Miren
dc.contributor.author Santa Marina, Loreto
dc.contributor.author Vrijheid, Martine
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Llop, Sabrina
dc.contributor.author Gonzalez-Palacios, Sandra
dc.contributor.author Meharg, Andrew A.
dc.date.accessioned 2025-01-14T08:15:05Z
dc.date.available 2025-01-14T08:15:05Z
dc.date.issued 2017
dc.description.abstract Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 μg/l (arsenobetaine—AsB), 3.97 μg/l (dimethylarsinic acid—DMA), 0.44 μg/l (monomethylarsonic acid—MMA) and 0.35 μg/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman’s correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.en
dc.description.sponsorship This work was funded by a Marie Curie Intra-European Fellowship within the 7th European Community Framework Programme (RICENIC project—PIEF-GA-2013-622096) and the INMA project (http://www.proyectoinma.org/), which is supported by grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1436, 04/1931, 04/2018, 05/1079, 05/1052, 06/0867, 06/1213, 07/0314, 08/1151, 09/00090, 09/02311, 09/02647, 11/0178, 11/01007, 11/02591, 11/02038, 13/1944, 13/2032, 13/02187, 13/02429, 14/0891, 14/1687 and Miguel Servet-FEDER CP15/00025), CIBERESP and the Conselleria de Sanitat, Generalitat Valenciana; Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430); Obra Social Cajastur/Fundación Liberbank and UNIVERSIDAD DE OVIEDO; Department of Health of the Basque Government (2005111093, 2009111069 and 2013111089), and the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001); Convenios anuales con los ayuntamientos de la zona del estudio (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain).en
dc.format.mimetype application/pdf
dc.identifier.citation Signes-Pastor AJ, Carey M, Vioque J, Navarrete-Muñoz EM, Rodríguez-Dehli C, Tardón A, et al. Urinary arsenic speciation in children and pregnant women from Spain. Expo Health. 2017 Jun;9(2):105-11. DOI: 10.1007/s12403-016-0225-7
dc.identifier.doi http://dx.doi.org/10.1007/s12403-016-0225-7
dc.identifier.issn 2451-9685
dc.identifier.uri http://hdl.handle.net/10230/69099
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Exposure and Health . 2017 Jun;9(2):105-11
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Arsenic speciationen
dc.subject.keyword Childrenen
dc.subject.keyword Pregnant womenen
dc.subject.keyword Biomarkeren
dc.subject.keyword Urinary metabolitesen
dc.subject.keyword Inorganic arsenicen
dc.title Urinary arsenic speciation in children and pregnant women from Spain
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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