Susceptible windows of prenatal and postnatal fine particulate matter exposures and attention-deficit hyperactivity disorder symptoms in early childhood

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• dc.contributor.author Chen, Wei-Jen
• dc.contributor.author Rector, Alison
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Iñiguez, Carmen
• dc.contributor.author Swartz, Michael D.
• dc.contributor.author Symanski, Elaine
• dc.contributor.author Ibarluzea, Jesús
• dc.contributor.author Valentín, Antònia
• dc.contributor.author Lertxundi, Aitana
• dc.contributor.author González-Safont, Llúcia
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Whitworth, Kristina W.
• dc.date.accessioned 2024-06-18T06:36:31Z
• dc.date.available 2024-06-18T06:36:31Z
• dc.date.issued 2024
• dc.description.abstract Few prior studies have explored windows of susceptibility to fine particulate matter (PM2.5) in both the prenatal and postnatal periods and children's attention-deficit/hyperactivity disorder (ADHD) symptoms. We analyzed data from 1416 mother-child pairs from the Spanish INMA (INfancia y Medio Ambiente) Study (2003-2008). Around 5 years of age, teachers reported the number of ADHD symptoms (i.e., inattention, hyperactivity/impulsivity) using the ADHD Diagnostic and Statistical Manual of Mental Disorders. Around 7 years of age, parents completed the Conners' Parent Rating Scales, from which we evaluated the ADHD index, cognitive problems/inattention, hyperactivity, and oppositional subscales, reported as age- and sex-standardized T-scores. Daily residential PM2.5 exposures were estimated using a two-stage random forest model with temporal back-extrapolation and averaged over 1-week periods in the prenatal period and 4-week periods in the postnatal period. We applied distributed lag non-linear models within the Bayesian hierarchical model framework to identify susceptible windows of prenatal or postnatal exposure to PM2.5 (per 5-μg/m3) for ADHD symptoms. Models were adjusted for relevant covariates, and cumulative effects were reported by aggregating risk ratios (RRcum) or effect estimates (βcum) across adjacent susceptible windows. A similar susceptible period of exposure to PM2.5 (1.2-2.9 and 0.9-2.7 years of age, respectively) was identified for hyperactivity/impulsivity symptoms assessed ~5 years (RRcum = 2.72, 95% credible interval [CrI] = 1.98, 3.74) and increased hyperactivity subscale ~7 years (βcum = 3.70, 95% CrI = 2.36, 5.03). We observed a susceptibility period to PM2.5 on risk of hyperactivity/impulsivity symptoms ~5 years in gestational weeks 16-22 (RRcum = 1.36, 95% CrI = 1.22, 1.52). No associations between PM2.5 exposure and other ADHD symptoms were observed. We report consistent evidence of toddlerhood as a susceptible window of PM2.5 exposure for hyperactivity in young children. Although mid-pregnancy was identified as a susceptible period of exposure on hyperactivity symptoms in preschool-aged children, this association was not observed at the time children were school-aged.
• dc.description.sponsorship This work was supported by grant R01ES028842 from the National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS); grants Red INMA G03/176, CB06/02/004; ISCIII-FEDER: PI03/1615, PI04/1509, PI04/1112, PI041436, PI04/1931, PI04/2018, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI081151 incl. FEDER funds, PI09/02311, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02429, PI14/00891, PI14/01687, PI16/1288, PI16/00118, PI17/00663, PI18/00909, PI18/01142, PI18/01237; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, CPII18/00018, and CP16/00128 from Instituto de Salud Carlos III, CIBERESP, grant 1999SGR 00241 from Generalitat de Catalunya-CIRIT, Generalitat de Catalunya-AGAUR 2009 SGR 501, Fundació La marató de TV3 (090430), grant FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, and grant number 261357 from the EU Commission, Assistance Award No. R-82811201 from the Health Effects Institute, grant UGP 15-230, UGP-15-244, and UGP-15-249 from Generalitat Valenciana: FISABIO, grant 2005111093 from Alicia Koplowitz Foundation 2017, Department of Health of the Basque Government, grant DFG06/002 from the Provincial Government of Gipuzkoa, and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), and Margarita Salas Grant MS21-125 co-funded by European Union- Next Generation EU and Ministerio de Universidades. We also acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program. KWW and ES were partially supported by the P30 Environmental Health Sciences Core Center grant P30ES030285 from the NIH/NIEHS and by funding from the NIH/National Institute on Minority Health and Health Disparities (NIMHD) under Award Number P50MD015496.
• dc.format.mimetype application/pdf
• dc.identifier.citation Chen WJ, Rector-Houze AM, Guxens M, Iñiguez C, Swartz MD, Symanski E, et al. Susceptible windows of prenatal and postnatal fine particulate matter exposures and attention-deficit hyperactivity disorder symptoms in early childhood. Sci Total Environ. 2024 Feb 20;912:168806. DOI: 10.1016/j.scitotenv.2023.168806
• dc.identifier.doi http://dx.doi.org/10.1016/j.scitotenv.2023.168806
• dc.identifier.issn 0048-9697
• dc.identifier.uri http://hdl.handle.net/10230/60499
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Sci Total Environ. 2024 Feb 20;912:168806
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Attention-deficit/hyperactivity disorder
• dc.subject.keyword Hyperactivity symptoms
• dc.subject.keyword PM(2.5)
• dc.subject.keyword Susceptible windows
• dc.title Susceptible windows of prenatal and postnatal fine particulate matter exposures and attention-deficit hyperactivity disorder symptoms in early childhood
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion