The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
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- dc.contributor.author Silva-Sousa, Ruteca
- dc.contributor.author Díaz Varela, Míriamca
- dc.contributor.author Casacuberta Suñer, Elena, 1972-ca
- dc.date.accessioned 2015-03-17T08:18:30Z
- dc.date.available 2015-03-17T08:18:30Z
- dc.date.issued 2013ca
- dc.description.abstract Background: Telomere maintenance in Drosophila relies on the targeted transposition of three very special non-LTR retrotransposons, HeT-A, TART, and TAHRE (HTT). The sequences of the retrotransposon array build up the telomere chromatin in this organism. We have recently reported the role of the chromosomal protein Putzig/Z4 in maintaining a proper chromatin structure at the telomere domain of Drosophila. Because the Putzig protein has been found in different cellular complexes related with cell proliferation, development, and immunity, we decided to investigate whether the previously described Putzig partners, DREF/TRF2 and KEN, could also be involved in the telomere function in this organism. Results: We have found that mutant alleles for Dref/Trf2 and Ken show alterations in HeT-A and TART expression, suggesting a possible role of these protein complexes in the regulation of the telomere retrotransposons. In agreement, both HeT-A and TART contain the specific DNA binding sequences for the DREF and the KEN protein proteins. Conclusions: We have identified three new negative regulators involved in the control of the expression of the telomeric retrotransposons, Dref, Trf2, and Ken. Our results offer some clues on which other chromatin-related proteins might be involved in telomere regulation and retrotransposon control.en
- dc.description.sponsorship This work was supported by a grant from the Spanish Ministry of Science and Innovation BFU2009-08318/BMC to EC, a PhD Fellowship Fundação para a Ciência e Tecnologia, Portugal SFRH / BD / 36291 / 2007 to RS-S, and a JAEintro (JAEINT_11_01262) from the CSIC to MDVen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Silva-Sousa R, Varela MD, Casacuberta E. The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART. Mobile DNA. 2013;4:18. DOI: 10.1186/1759-8753-4-18ca
- dc.identifier.doi http://dx.doi.org/10.1186/1759-8753-4-18
- dc.identifier.issn 1759-8753ca
- dc.identifier.uri http://hdl.handle.net/10230/23201
- dc.language.iso engca
- dc.publisher BioMed Centralca
- dc.relation.ispartof Mobile DNA. 2013;4:18
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-08318
- dc.rights © 2013 Silva-Sousa et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/2.0
- dc.subject.other Drosòfila -- Genèticaca
- dc.subject.other Cromosomesca
- dc.subject.other Proteïnesca
- dc.title The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TARTen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca