Electrocardiographic distinction of left circumflexand right coronary artery occlusion in patients with inferior acute myocardial infarction

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• dc.contributor.author Vives-Borras, Miquel
• dc.contributor.author Maestro, Alba
• dc.contributor.author García-Hernando, Vıctor
• dc.contributor.author Jorgensen, David
• dc.contributor.author Ferrero-Gregori, Andreu
• dc.contributor.author Moustafa, Abdel-Hakim
• dc.contributor.author Solé-González, Eduard
• dc.contributor.author Noriega; Francisco J.
• dc.contributor.author Álvarez-García, Jesus
• dc.contributor.author Cinca, Juan
• dc.date.accessioned 2019-06-04T07:29:03Z
• dc.date.available 2019-06-04T07:29:03Z
• dc.date.issued 2019
• dc.description.abstract Previously reported electrocardiographic (ECG) criteria to distinguish left circumflex (LCCA) and right coronary artery (RCA) occlusion in patients with acute inferior ST-segment elevation myocardial infarction (STEMI) afford a modest diagnostic accuracy. We aimed to develop a new algorithm overcoming limitations of previous studies. Clinical, ECG, and coronary angiographic data were analyzed in 230 nonselected patients with acute inferior STEMI who underwent primary percutaneous coronary intervention. A decision-tree analysis was used to develop a new ECG algorithm. The diagnostic accuracy of reported ECG criteria was reviewed. LCCA occlusion occurred in 111 cases and RCA in 119. We developed a 3-step algorithm that identified LCCA and RCA occlusion with a sensitivity of 77%, specificity of 86%, accuracy of 82%, and Youden index of 0.63. The area under the ROC curve was 0.85 and resulted 0.82 after a 10-fold cross validation. The key leads for LCCA occlusion were V3 (ST depression in V3/ST elevation in III >1.2) and V6 (ST elevation ≥0.1 mV or greater than III). The key leads for RCA occlusion were I and aVL (ST depression ≥ 0.1 mV). Fifteen of 21 reviewed studies had less than 20 cases of LCCA occlusion, only 48% performed primary percutaneous coronary intervention, and previous infarction or multivessel disease were often excluded. The diagnostic accuracy of reported ECG criteria decreased when applied to our study population. In conclusion, we report a simple and highly discriminative 3-step ECG algorithm to differentiate LCCA and RCA occlusion in an "all comers" population of patients with acute inferior STEMI. The diagnostic key ECG leads were V3 and V6 for LCCA and I and aVL for RCA occlusion.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vives-Borrás M, Maestro A, García-Hernando V, Jorgensen D, Ferrero-Gregori A, Moustafa AH. Et al. Electrocardiographic distinction of left circumflexand right coronary artery occlusion in patients with inferior acute myocardial infarction. Am J Cardiol. 2019 Apr 1;123(7):1019-1025. DOI: 10.1016/j.amjcard.2018.12.026
• dc.identifier.doi http://dx.doi.org/10.1016/j.amjcard.2018.12.026
• dc.identifier.issn 0002-9149
• dc.identifier.uri http://hdl.handle.net/10230/41693
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/) (Am J Cardiol 2019;123:1019−1025)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Artèries -- Malalties
• dc.subject.other Infart de miocardi
• dc.title Electrocardiographic distinction of left circumflexand right coronary artery occlusion in patients with inferior acute myocardial infarction
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion