A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.

Pastor, Antonio; Fernández Aranda, Fernando; Fitó Colomer, Montserrat; Jiménez Murcia, Susana; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Tinahones Madueño, Francisco José; Fagundo, Ana B.; Rodríguez Rodríguez, Juan Francisco; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; Torre Fornell, Rafael de la

A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.

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dc.contributor.author Pastor, Antonioca
dc.contributor.author Fernández Aranda, Fernandoca
dc.contributor.author Fitó Colomer, Montserratca
dc.contributor.author Jiménez Murcia, Susanaca
dc.contributor.author Botella, Cristinaca
dc.contributor.author Fernández Real, Jose M.ca
dc.contributor.author Frühbeck, Gemaca
dc.contributor.author Tinahones Madueño, Francisco Joséca
dc.contributor.author Fagundo, Ana B.ca
dc.contributor.author Rodríguez Rodríguez, Juan Franciscoca
dc.contributor.author Agüera, Zaidaca
dc.contributor.author Langohr, Klausca
dc.contributor.author Casanueva, Felipe F.ca
dc.contributor.author Torre Fornell, Rafael de laca
dc.date.accessioned 2016-04-11T08:00:06Z
dc.date.available 2016-04-11T08:00:06Z
dc.date.issued 2016
dc.description.abstract The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible interaction between olfaction, obesity and the eCB system. The study sample was made up of 161 females with five groups of body mass index sub-categories ranging from under-weight to morbidly obese. We assessed olfactory capacity with the "Sniffin´Sticks" test, which measures olfactory threshold-discrimination-identification (TDI) capacity. We measured plasma concentrations of the eCBs 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine or anandamide (AEA), and several eCB-related compounds, 2-acylglycerols and N-acylethanolamines. 2-AG and other 2-acylglycerols fasting plasma circulating plasma concentrations were higher in obese and morbidly obese subjects. AEA and other N-acylethanolamine circulating concentrations were lower in under-weight subjects. Olfactory TDI scores were lower in obese and morbidly obese subjects. Lower TDI scores were independently associated with higher 2-AG fasting plasma circulating concentrations, higher %body fat, and higher body mass index, after controlling for age, smoking, menstruation, and use of contraceptives. Our results show that obese subjects have a lower olfactory capacity than non-obese ones and that elevated fasting plasma circulating 2-AG concentrations in obesity are linked to a lower olfactory capacity. In agreement with previous studies we show that eCBs AEA and 2-AG, and their respective congeners have a distinct profile in relation to body mass index. The present report is the first study in humans in which olfactory capacity and circulating eCB concentrations have been measured in the same subjects.ca
dc.description.sponsorship The work was supported by the following:Instituto Salud Carlos III,http://www.isciii.es, FISPI11/210, FIS14/290; Centro de InvestigaciónBiomédica en Red. Fisiopatología de la Obesidad yNutrición (CIBEROB),http://www.ciberobn.es; and Agència de Gestió d ́Ajuts Universitaris i de Recerca(AGAUR),www.gencat.cat/agaur/, 2014 SGR 1672.
dc.format.mimetype application/pdfca
dc.identifier.citation Pastor A1,2,3, Fernández-Aranda F4,3, Fitó M5,3, Jiménez-Murcia S4,6,3, Botella C7,3, Fernández-Real JM. et al. A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women. PLoS One. 2016 Feb 5;11(2):e0148734. doi: 10.1371/journal.pone.0148734.ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0148734
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/26066
dc.language.iso engca
dc.publisher Public Library of Science ca
dc.relation.ispartof PLoS One. 2016 Feb 5;11(2):e0148734
dc.rights © 2016 Pastor et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source arecreditedca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Olfacteca
dc.subject.other Obesitatca
dc.title A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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