Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

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• dc.contributor.author Wexler, Judith
• dc.contributor.author Delaney, Emily Kay
• dc.contributor.author Bellés, Xavier, 1952-
• dc.contributor.author Schal, Coby
• dc.contributor.author Wada-Katsumata, Ayako
• dc.contributor.author Amicucci, Matthew J.
• dc.contributor.author Kopp, Artyom
• dc.date.accessioned 2020-05-28T07:37:00Z
• dc.date.available 2020-05-28T07:37:00Z
• dc.date.issued 2019
• dc.description.abstract Insects are the only known animals in which sexual differentiation is controlled by sex-specific splicing. The doublesex transcription factor produces distinct male and female isoforms, which are both essential for sex-specific development. dsx splicing depends on transformer, which is also alternatively spliced such that functional Tra is only present in females. This pathway has evolved from an ancestral mechanism where dsx was independent of tra and expressed and required only in males. To reconstruct this transition, we examined three basal, hemimetabolous insect orders: Hemiptera, Phthiraptera, and Blattodea. We show that tra and dsx have distinct functions in these insects, reflecting different stages in the changeover from a transcription-based to a splicing-based mode of sexual differentiation. We propose that the canonical insect tra-dsx pathway evolved via merger between expanding dsx function (from males to both sexes) and narrowing tra function (from a general splicing factor to dedicated regulator of dsx).
• dc.format.mimetype application/pdf
• dc.identifier.citation Wexler J, Delaney EK, Belles X, Schal C, Wada-Katsumata A, Amicucci MJ, Kopp A. Hemimetabolous insects elucidate the origin of sexual development via alternative splicing. Elife. 2019; 8:e47490. DOI: 10.7554/eLife.47490
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.47490
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/44840
• dc.language.iso eng
• dc.publisher eLife
• dc.relation.ispartof Elife. 2019; 8:e47490
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CGL2012-36251
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2015-64727-P
• dc.rights © 2019, Wexler et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Blattella germanica
• dc.subject.keyword Development
• dc.subject.keyword Developmental biology
• dc.subject.keyword Doublesex
• dc.subject.keyword Evolution
• dc.subject.keyword Evolutionary biology
• dc.subject.keyword Sex
• dc.subject.keyword Transformer
• dc.title Hemimetabolous insects elucidate the origin of sexual development via alternative splicing
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion