DNA methylation signature as a biomarker of major neuropsychiatric disorders
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- dc.contributor.author Shirvani Farsani, Zeinab
- dc.contributor.author Maloum, Zahra
- dc.contributor.author Bagheri Hosseinabadi, Zahra
- dc.contributor.author Vilor Tejedor, Natàlia, 1988-
- dc.contributor.author Sadeghi, Iman
- dc.contributor.author Sadeghi, Iman
- dc.date.accessioned 2021-07-23T06:58:49Z
- dc.date.issued 2021
- dc.description.abstract DNA methylation is a broadly-investigated epigenetic modification that has been considered as a heritable and reversible change. Previous findings have indicated that DNA methylation regulates gene expression in the central nervous system (CNS). Also, disturbance of DNA methylation patterns has been associated with destructive consequences that lead to human brain diseases such as neuropsychiatric disorders (NPDs). In this review, we comprehensively discuss the mechanism and function of DNA methylation and its most recent associations with the pathology of NPDs-including major depressive disorder (MDD), schizophrenia (SZ), autism spectrum disorder (ASD), bipolar disorder (BD), and attention/deficit hyperactivity disorder (ADHD). We also discuss how heterogeneous findings demand further investigations. Finally, based on the recent studies we conclude that DNA methylation status may have implications in clinical diagnostics and therapeutics as a potential epigenetic biomarker of NPDs.
- dc.format.mimetype application/pdf
- dc.identifier.citation Shirvani-Farsani Z, Maloum Z, Bagheri-Hosseinabadi Z, Vilor-Tejedor N, Sadeghi I. DNA methylation signature as a biomarker of major neuropsychiatric disorders. J Psychiatr Res. 2021;141:34-49. DOI: 10.1016/j.jpsychires.2021.06.013
- dc.identifier.doi http://dx.doi.org/10.1016/j.jpsychires.2021.06.013
- dc.identifier.issn 0022-3956
- dc.identifier.uri http://hdl.handle.net/10230/48287
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof J Psychiatr Res. 2021;141:34-49
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.jpsychires.2021.06.013
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword ADHD
- dc.subject.keyword Autism
- dc.subject.keyword Bipolar
- dc.subject.keyword Brain disease
- dc.subject.keyword DNA methylation
- dc.subject.keyword Major depressive disorder
- dc.subject.keyword Schizophrenia
- dc.title DNA methylation signature as a biomarker of major neuropsychiatric disorders
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion