Exposure to medical radiation during fetal life, childhood and adolescence and risk of brain tumor in young age: results from the MOBI-Kids Case-Control Study

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  • dc.contributor.author Pasqual, Elisa, 1989-
  • dc.contributor.author Castaño Vinyals, Gemma
  • dc.contributor.author Thierry-Chef, Isabelle
  • dc.contributor.author Cardis, Elisabeth
  • dc.date.accessioned 2021-04-27T09:46:30Z
  • dc.date.available 2021-04-27T09:46:30Z
  • dc.date.issued 2020
  • dc.description.abstract Background: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. Methods: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. Results: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. Conclusions: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
  • dc.description.sponsorship This work was funded by the EC Seventh Framework Programme (FP7/2007–2013) under the MOBI-Kids project (Grant No. 226873) and GERoNiMO project (Grant No. 603794). International coordination of the project was also supported by the Spanish Ministry of Science and Innovation (Grant EUS2008-03626). It has also been supported by the Spanish Health Research Fund (FIS PI10/02981), the Andalusian Consejeria de Salud (PI-0317/2010) and Conselleria de Sanitat, Generalitat Valenciana (Grant No. 025/2010.)
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pasqual E, Castaño-Vinyals G, Thierry-Chef I, Kojimahara N, Sim MR, Kundi M et al. Exposure to medical radiation during fetal life, childhood and adolescence and risk of brain tumor in young age: results from the MOBI-Kids Case-Control Study. Neuroepidemiology. 2020;54(4):343-355. DOI: 10.1159/000506131
  • dc.identifier.doi http://dx.doi.org/10.1159/000506131
  • dc.identifier.issn 0251-5350
  • dc.identifier.uri http://hdl.handle.net/10230/47228
  • dc.language.iso eng
  • dc.publisher Karger (S. Karger AG)
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226873
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/EUS2008-03626
  • dc.rights © 2020 S. Karger AG, Basel http://dx.doi.org/10.1159/000506131 ‘This is the peer-reviewed but unedited manuscript version of the following article: Pasqual E, Castaño-Vinyals G, Thierry-Chef I, Kojimahara N, Sim MR, Kundi M et al. Exposure to medical radiation during fetal life, childhood and adolescence and risk of brain tumor in young age: results from the MOBI-Kids Case-Control Study. Neuroepidemiology. 2020;54(4):343-355
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Radiologia mèdica
  • dc.subject.other Cervell -- Tumors
  • dc.subject.other Fetus -- Malalties
  • dc.subject.other Infants -- Malalties
  • dc.subject.other Adolescents -- Malalties
  • dc.title Exposure to medical radiation during fetal life, childhood and adolescence and risk of brain tumor in young age: results from the MOBI-Kids Case-Control Study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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