Signatures of selection in the human olfactory receptor OR5I1 gene
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- dc.contributor.author Moreno Estrada, Andrésca
- dc.contributor.author Casals López, Ferran
- dc.contributor.author Ramírez Soriano, Anna
- dc.contributor.author Oliva Miguel, Baldomero
- dc.contributor.author Calafell i Majó, Francesc
- dc.contributor.author Bertranpetit, Jaume, 1952-
- dc.contributor.author Bosch Fusté, Elena
- dc.date.accessioned 2011-07-27T08:27:50Z
- dc.date.available 2011-07-27T08:27:50Z
- dc.date.issued 2008ca
- dc.description.abstract The human olfactory receptor repertoire is reduced in comparison to other mammals/nand to other non-human primates. Nonetheless, this olfactory decline opens an opportunity for/nevolutionary innovation and improvement. In the present study, we focus on an olfactory/nreceptor gene, OR5I1, which had previously been shown to present an excess of amino acid/nreplacement substitutions between humans and chimpanzees. We analyze the genetic/nvariation in OR5I1 in a large worldwide human panel and find an excess of derived alleles/nsegregating at relatively high frequencies in all populations. Additional evidence for selection/nincludes departures from neutrality in allele frequency spectra tests but no unusually extended/nhaplotype structure. Moreover, molecular structural inference suggests that one of the/nnonsynonymous polymorphisms defining the presumably adaptive protein form of OR5I1/nmay alter the functional binding properties of the olfactory receptor. These results are/ncompatible with positive selection having modeled the pattern of variation found in the OR5I1/ngene and with a relatively ancient, mild selective sweep predating the “Out of Africa”/nexpansion of modern humans.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Moreno-Estrada A, Casals F, Ramírez-Soriano A, Oliva B, Calafell F, Bertranpetit J, Bosch E. Signatures of selection in the human olfactory receptor OR5I1 gene. Mol Biol Evol. 2008;25(1):144-54. DOI: 10.1093/molbev/msm240
- dc.identifier.doi http://dx.doi.org/10.1093/molbev/msm240
- dc.identifier.uri http://hdl.handle.net/10230/12422
- dc.language.iso engca
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Molecular Biology and Evolution. 2008;25(1):144-54
- dc.rights © Oxford University Press.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Olfactory receptors
- dc.subject.keyword Single nucleotide polymorphisms
- dc.subject.keyword Human variation
- dc.subject.keyword Positive selection
- dc.subject.other Genètica humana -- Variació
- dc.subject.other Selecció natural
- dc.title Signatures of selection in the human olfactory receptor OR5I1 geneca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersion