Family history and gastric cancer risk: A pooled investigation in the stomach cancer pooling (STOP) project consortium

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  • dc.contributor.author Vitelli Storelli, Facundo
  • dc.contributor.author Castaño Vinyals, Gemma
  • dc.contributor.author Martín, Vicente
  • dc.date.accessioned 2022-04-29T06:43:47Z
  • dc.date.available 2022-04-29T06:43:47Z
  • dc.date.issued 2021
  • dc.description.abstract Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64-2.04; I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82; 95% CI: 1.59-2.05 for subjects with FH) than for cardia GC (OR = 1.38; 95% CI: 0.98-1.77), and for the intestinal (OR = 1.92; 95% CI: 1.62-2.23) than for the diffuse histotype (OR = 1.62; 95% CI: 1.28-1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Vitelli-Storelli F, Rubín-García M, Pelucchi C, Benavente Y, Bonzi R, Rota M et al. Family history and gastric cancer risk: A pooled investigation in the stomach cancer pooling (STOP) project consortium. Cancers (Basel). 2021 Jul 30;13(15):3844. DOI: 10.3390/cancers13153844
  • dc.identifier.doi http://dx.doi.org/10.3390/cancers13153844
  • dc.identifier.issn 2072-6694
  • dc.identifier.uri http://hdl.handle.net/10230/52939
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Cancers (Basel). 2021 Jul 30;13(15):3844
  • dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Family history
  • dc.subject.keyword Gastric cancer
  • dc.subject.keyword International consortium
  • dc.subject.keyword Meta-analyses
  • dc.title Family history and gastric cancer risk: A pooled investigation in the stomach cancer pooling (STOP) project consortium
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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