Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
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- dc.contributor.author Escudero-Lara, Alejandra
- dc.contributor.author Argerich, Josep
- dc.contributor.author Cabañero Ferri, David
- dc.contributor.author Maldonado, Rafael, 1961-
- dc.date.accessioned 2020-01-21T08:52:40Z
- dc.date.available 2020-01-21T08:52:40Z
- dc.date.issued 2020
- dc.description.abstract Endometriosis is a chronic painful disease highly prevalent in women that is defined by growth of endometrial tissue outside the uterine cavity and lacks adequate treatment. Medical use of cannabis derivatives is a current hot topic and it is unknown whether phytocannabinoids may modify endometriosis symptoms and development. Here we evaluate the effects of repeated exposure to Δ9-tetrahydrocannabinol (THC) in a mouse model of surgically-induced endometriosis. In this model, female mice develop mechanical hypersensitivity in the caudal abdomen, mild anxiety-like behavior and substantial memory deficits associated with the presence of extrauterine endometrial cysts. Interestingly, daily treatments with THC (2 mg/kg) alleviate mechanical hypersensitivity and pain unpleasantness, modify uterine innervation and restore cognitive function without altering the anxiogenic phenotype. Strikingly, THC also inhibits the development of endometrial cysts. These data highlight the interest of scheduled clinical trials designed to investigate possible benefits of THC for women with endometriosis.
- dc.description.sponsorship Funding: “Instituto de Salud Carlos III”, “Redes temáticas de investigación cooperativa en salud – Red de trastornos adictivos” (#RD16/0017/0020), “Ministerio de Ciencia, Innovación y Universidades”, MCIU (#SAF2017-84060-R-AEI/FEDER-UE), “Generalitat de Catalunya - Agència de Gestió d'Ajuts Universitaris i de Recerca-AGAUR" (#2017-SGR422 669 and #ICREA Acadèmia2015) to R.M. are acknowledged
- dc.format.mimetype application/pdf
- dc.identifier.citation Escudero-Lara A, Argerich, J, Cabañero D, Maldonado R. Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain. Elife. 2020;9:e50356. DOI: 10.7554/eLife.50356
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.50356
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/43315
- dc.language.iso eng
- dc.publisher Elife Science Publications
- dc.relation.ispartof Elife. 2020;9:e50356
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-84060-R
- dc.rights © 2020, Escudero-Lara et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Biologia humana
- dc.subject.other Medicina
- dc.subject.other Ratolins
- dc.subject.other Neurociències
- dc.title Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion