Dynamic interactions between the genome and an endogenous retrovirus: tirant in Drosophila simulans wild-type strains

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• dc.contributor.author Fablet, Marie
• dc.contributor.author Jacquet, Angelo
• dc.contributor.author Rebollo, Rita
• dc.contributor.author Haudry, Annabelle
• dc.contributor.author Rey, Carine
• dc.contributor.author Salces Ortiz, Judit
• dc.contributor.author Bajad, Prajakta
• dc.contributor.author Burlet, Nelly
• dc.contributor.author Jantsch, Michael F.
• dc.contributor.author García Guerreiro, Maria Pilar
• dc.contributor.author Vieira, Cristina
• dc.date.accessioned 2020-06-09T06:13:23Z
• dc.date.available 2020-06-09T06:13:23Z
• dc.date.issued 2019
• dc.description.abstract All genomes contain repeated sequences that are known as transposable elements (TEs). Among these are endogenous retroviruses (ERVs), which are sequences similar to retroviruses and are transmitted across generations from parent to progeny. These sequences are controlled in genomes through epigenetic mechanisms. At the center of the epigenetic control of TEs are small interfering RNAs of the piRNA class, which trigger heterochromatinization of TE sequences. The tirant ERV of Drosophila simulans displays intra-specific variability in copy numbers, insertion sites, and transcription levels, providing us with a well-suited model to study the dynamic relationship between a TE family and the host genome through epigenetic mechanisms. We show that tirant transcript amounts and piRNA amounts are positively correlated in ovaries in normal conditions, unlike what was previously described following divergent crosses. In addition, we describe tirant insertion polymorphism in the genomes of three D. simulans wild-type strains, which reveals a limited number of insertions that may be associated with gene transcript level changes through heterochromatin spreading and have phenotypic impacts. Taken together, our results participate in the understanding of the equilibrium between the host genome and its TEs.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fablet M, Jacquet A, Rebollo R, Haudry A, Rey C, Salces-Ortiz J, Bajad P, Burlet N, Jantsch MF, Guerreiro MPG, Vieira C. Dynamic interactions between the genome and an endogenous retrovirus: tirant in Drosophila simulans wild-type strains. G3 (Bethesda). 2019; 9(3):855-65. DOI: 10.1534/g3.118.200789
• dc.identifier.doi http://dx.doi.org/10.1534/g3.118.200789
• dc.identifier.issn 2160-1836
• dc.identifier.uri http://hdl.handle.net/10230/44932
• dc.language.iso eng
• dc.publisher Genetics Society of America
• dc.relation.ispartof G3 (Bethesda). 2019; 9(3):855-65
• dc.rights © 2019 Fablet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Drosophila
• dc.subject.keyword Retrotransposon
• dc.subject.keyword Transposable element
• dc.subject.keyword Chromatin
• dc.subject.keyword Epigenetic control
• dc.subject.keyword piRNA
• dc.title Dynamic interactions between the genome and an endogenous retrovirus: tirant in Drosophila simulans wild-type strains
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion