Control of Cdc28 CDK1 by a stress-induced lncRNA

Nadal Ribelles, Mariona, 1984-; Solé, Carme; Xu, Zhenyu; Steinmetz, Lars M.; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc

Control of Cdc28 CDK1 by a stress-induced lncRNA

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dc.contributor.author Nadal Ribelles, Mariona, 1984-ca
dc.contributor.author Solé, Carmeca
dc.contributor.author Xu, Zhenyuca
dc.contributor.author Steinmetz, Lars M.ca
dc.contributor.author Nadal Clanchet, Eulàlia deca
dc.contributor.author Posas Garriga, Francescca
dc.date.accessioned 2015-06-16T08:18:16Z
dc.date.available 2015-06-16T08:18:16Z
dc.date.issued 2014ca
dc.description.abstract Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon environmental changes. Upon osmostress, hundreds of stress-responsive genes are induced by the stress-activated protein kinase (SAPK) p38/Hog1. Using whole-genome tiling arrays, we found that Hog1 induces a set of lncRNAs upon stress. One of the genes expressing a Hog1-dependent lncRNA in antisense orientation is CDC28, the cyclin-dependent kinase 1 (CDK1) that controls the cell cycle in yeast. Cdc28 lncRNA mediates the establishment of gene looping and the relocalization of Hog1 and RSC from the 3′ UTR to the +1 nucleosome to induce CDC28 expression. The increase in the levels of Cdc28 results in cells able to reenter the cell cycle more efficiently after stress. This may represent a general mechanism to prime expression of genes needed after stresses are alleviated.en
dc.description.sponsorship This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2012-33503 and FEDER to F.P., BFU2011-26722 to E.d.N.), the Fundación Marcelino Botín (FMB), and the Consolider Ingenio 2010 programme CSD2007-0015 (to F.P.). This work was supported by the National Institutes of Health and Deutsche Forschungsgemeinschaft (L.M.S.). F.P. and E.d.N. are recipients of an ICREA Acadèmia award (Generalitat de Catalunya).en
dc.format.mimetype application/pdfca
dc.identifier.citation Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. Control of Cdc28 CDK1 by a stress-induced lncRNA. Molecular Cell. 2014;53(4):549-61. DOI: 10.1016/j.molcel.2014.01.006ca
dc.identifier.doi http://dx.doi.org/10.1016/j.molcel.2014.01.006
dc.identifier.issn 1097-2765ca
dc.identifier.uri http://hdl.handle.net/10230/23826
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof Molecular Cell. 2014;53(4):549-61
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-33503
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26722
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-0015
dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.molcel.2014.01.006 that appeared in the journal Molecular Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseen
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Proteïnes quinases -- Metabolismeca
dc.subject.other Saccharomyces cerevisiae -- Metabolismeca
dc.subject.other Transcripció genèticaca
dc.title Control of Cdc28 CDK1 by a stress-induced lncRNAen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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