Encoding membrane-potential-based memory within a microbial community
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- dc.contributor.author Yang, Chih-Yu
- dc.contributor.author Bialecka-Fornal, Maja
- dc.contributor.author Weatherwax, Colleen
- dc.contributor.author Larkin, Joseph
- dc.contributor.author Prindle, Arthur
- dc.contributor.author Liu, Jintao
- dc.contributor.author García Ojalvo, Jordi
- dc.contributor.author Süel, Gürol M.
- dc.date.accessioned 2022-01-26T07:34:00Z
- dc.date.available 2022-01-26T07:34:00Z
- dc.date.issued 2020
- dc.description.abstract Cellular membrane potential plays a key role in the formation and retrieval of memories in the metazoan brain, but it remains unclear whether such memory can also be encoded in simpler organisms like bacteria. Here, we show that single-cell-level memory patterns can be imprinted in bacterial biofilms by light-induced changes in the membrane potential. We demonstrate that transient optical perturbations generate a persistent and robust potassium-channel-mediated change in the membrane potential of bacteria within the biofilm. The light-exposed cells respond in an anti-phase manner, relative to unexposed cells, to both natural and induced oscillations in extracellular ion concentrations. This anti-phase response, which persists for hours following the transient optical stimulus, enables a direct single-cell resolution visualization of spatial memory patterns within the biofilm. The ability to encode robust and persistent membrane-potential-based memory patterns could enable computations within prokaryotic communities and suggests a parallel between neurons and bacteria.
- dc.description.sponsorship We thank Leticia Galera-Laporta, Dong-yeon D. Lee, and Kaito Kikuchi for useful discussions; G.M.S. acknowledges support for this research from the National Institute of General Medical Sciences (grant R01 GM121888 to G.M.S.) and the Howard Hughes Medical Institute-Simons Foundation Faculty Scholars program. J.G.-O. acknowledges support from the Spanish Ministry of Science, Innovation and Universities and FEDER (project PGC2018-101251-B-I00 and “' Maria de Maeztu ” Programme for Units of Excellence in R\&D, grant CEX2018-000792-M) , and from the Generalitat de Catalunya (ICREA Academia programme).
- dc.format.mimetype application/pdf
- dc.identifier.citation Yang CY, Bialecka-Fornal M, Weatherwax C, Larkin JW, Prindle A, Liu J, Garcia-Ojalvo J, Süel GM. Encoding membrane-potential-based memory within a microbial community. Cell Syst. 2020;10(5):417-423.e3. DOI: 10.1016/j.cels.2020.04.002
- dc.identifier.doi http://dx.doi.org/10.1016/j.cels.2020.04.002
- dc.identifier.issn 2405-4712
- dc.identifier.uri http://hdl.handle.net/10230/52324
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cell Syst. 2020;10(5):417-423.e3
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
- dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.cels.2020.04.002 that appeared in the journal Cell systems. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: https://www.elsevier.com/about/our-business/policies/open-access-licenses/elsevier-user-license
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://www.elsevier.com/open-access/userlicense/1.0/
- dc.subject.keyword Hodgkin-Huxley
- dc.subject.keyword Anti-phase
- dc.subject.keyword Biofilm
- dc.subject.keyword Ion channels
- dc.subject.keyword Membrane potential
- dc.subject.keyword Memory
- dc.subject.keyword Microbial communities
- dc.subject.keyword Optical
- dc.subject.keyword Persistent
- dc.subject.keyword Robust
- dc.title Encoding membrane-potential-based memory within a microbial community
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion