Optimising clinical epidemiology in disease outbreaks: Analysis of ISARIC-WHO COVID-19 case report form utilisation

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• dc.contributor.author Merson, Laura
• dc.contributor.author Duque, Sara
• dc.contributor.author Garcia-Gallo, Esteban
• dc.contributor.author Yeabah, Trokon Omarley
• dc.contributor.author Rylance, Jamie
• dc.contributor.author Diaz, Janet
• dc.contributor.author Flahault, Antoine
• dc.contributor.author ISARIC Clinical Characterisation Group
• dc.date.accessioned 2025-04-02T12:21:14Z
• dc.date.available 2025-04-02T12:21:14Z
• dc.date.issued 2024
• dc.description.abstract Standardised forms for capturing clinical data promote consistency in data collection and analysis across research sites, enabling faster, higher-quality evidence generation. ISARIC and the World Health Organization have developed case report forms (CRFs) for the clinical characterisation of several infectious disease outbreaks. To improve the design and quality of future forms, we analysed the inclusion and completion rates of the 243 fields on the ISARIC-WHO COVID-19 CRF. Data from 42 diverse collaborations, covering 1886 hospitals and 950,064 patients, were analysed. A mean of 129.6 fields (53%) were included in the adapted CRFs implemented across the sites. Consistent patterns of field inclusion and completion aligned with globally recognised research priorities in outbreaks of novel infectious diseases. Outcome status was the most highly included (95.2%) and completed (89.8%) field, followed by admission demographics (79.1% and 91.6%), comorbidities (77.9% and 79.0%), signs and symptoms (68.9% and 78.4%), and vitals (70.3% and 69.1%). Mean field completion was higher in severe patients (70.2%) than in all patients (61.6%). The results reveal how clinical characterisation CRFs can be streamlined to reduce data collection time, including the modularisation of CRFs, to offer a choice of data volume collection and the separation of critical care interventions. This data-driven approach to designing CRFs enhances the efficiency of data collection to inform patient care and public health response.
• dc.format.mimetype application/pdf
• dc.identifier.citation Merson L, Duque S, Garcia-Gallo E, Yeabah TO, Rylance J, Diaz J, et al. Optimising clinical epidemiology in disease outbreaks: Analysis of ISARIC-WHO COVID-19 case report form utilisation. Epidemiologia (Basel). 2024 Aug 30;5(3):557-80. DOI: 10.3390/epidemiologia5030039
• dc.identifier.doi http://dx.doi.org/10.3390/epidemiologia5030039
• dc.identifier.issn 2673-3986
• dc.identifier.uri http://hdl.handle.net/10230/70079
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Epidemiologia (Basel). 2024 Aug 30;5(3):557-80
• dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword ISARIC
• dc.subject.keyword Clinical epidemiology
• dc.subject.keyword Common data elements
• dc.subject.keyword Data collection
• dc.subject.keyword Data management
• dc.subject.keyword Infectious disease outbreaks
• dc.title Optimising clinical epidemiology in disease outbreaks: Analysis of ISARIC-WHO COVID-19 case report form utilisation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion