Evolution of Tandem Repeat Satellite Sequences in Two Closely Related Caenorhabditis Species. Diminution of Satellites in Hermaphrodites

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• dc.contributor.author Subirana, Juan A.ca
• dc.contributor.author Messeguer, Xavier
• dc.date.accessioned 2018-05-31T07:48:53Z
• dc.date.available 2018-05-31T07:48:53Z
• dc.date.issued 2017
• dc.description.abstract The availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to understand the evolutionary dynamics of their tandem repeat sequences (satellites), as a result of evolution from the unisexual ancestor. We take advantage of the previously developed SATFIND program to build satellite families defined by a consensus sequence. The relative number of satellites (satellites/Mb) in C. nigoni is 24.6% larger than in C. briggsae. Some satellites in C. nigoni have developed from a proto-repeat present in the ancestor species and are conserved as an isolated sequence in C. briggsae. We also identify unique satellites which occur only once and joint satellite families with a related sequence in both species. Some of these families are only found in C. nigoni, which indicates a recent appearance; they contain conserved adjacent 5' and 3' regions, which may favor transposition. Our results show that the number, length and turnover of satellites are restricted in the hermaphrodite C. briggsae when compared with the unisexual C. nigoni. We hypothesize that this results from differences in unequal recombination during meiotic chromosome pairing, which limits satellite turnover in hermaphrodites.
• dc.description.sponsorship We are most thankful to Erich M. Schwarz for providing the C. nigoni genome data and a preprint of their work ahead of publication. We also thank M. Mar Albà and Ben Lehner for fruitful discussions and advice. This work was supported in part by project TIN2015-69175-C4-3-R (MINECO-FEDER, UE), including funds for covering the costs to publish in open access.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Subirana JA, Messeguer X. Evolution of Tandem Repeat Satellite Sequences in Two Closely Related Caenorhabditis Species. Diminution of Satellites in Hermaphrodites. Genes. 2017;8(12):351. DOI: 10.3390/genes8120351
• dc.identifier.doi http://dx.doi.org/10.3390/genes8120351
• dc.identifier.issn 2073-4425
• dc.identifier.uri http://hdl.handle.net/10230/34760
• dc.language.iso eng
• dc.publisher MDPIca
• dc.relation.ispartof Genes. 2017;8(12):351
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2015-69175-C4-3-R
• dc.rights © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Caenorhabditis briggssae
• dc.subject.keyword Caenorhabditis nigoni
• dc.subject.keyword hermaphroditism
• dc.subject.keyword Nematodes
• dc.subject.keyword satellite DNA
• dc.subject.keyword Tandem repeat sequences
• dc.subject.other Intersexualitat
• dc.title Evolution of Tandem Repeat Satellite Sequences in Two Closely Related Caenorhabditis Species. Diminution of Satellites in Hermaphroditesca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion