The influence of genetic and environmental factors among MDMA users in cognitive performance

Cuyàs, Elisabet; Verdejo García, Antonio; Fagundo, Ana B.; Khymenets, Olha, 1974-; Rodríguez, Joan; Cuenca Royo, Aida Ma, 1981-; De Sola Llopis, Susana; Langohr, Klaus; Peña-Casanova, J. (Jordi); Torrens, Marta; Martín Santos, Rocío; Farré Albaladejo, Magí; Torre Fornell, Rafael de la

The influence of genetic and environmental factors among MDMA users in cognitive performance

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dc.contributor.author Cuyàs, Elisabetca
dc.contributor.author Verdejo García, Antonioca
dc.contributor.author Fagundo, Ana B.ca
dc.contributor.author Khymenets, Olha, 1974-ca
dc.contributor.author Rodríguez, Joanca
dc.contributor.author Cuenca Royo, Aida Ma, 1981-ca
dc.contributor.author De Sola Llopis, Susanaca
dc.contributor.author Langohr, Klausca
dc.contributor.author Peña-Casanova, J. (Jordi)ca
dc.contributor.author Torrens, Martaca
dc.contributor.author Martín Santos, Rocíoca
dc.contributor.author Farré Albaladejo, Magíca
dc.contributor.author Torre Fornell, Rafael de laca
dc.date.accessioned 2015-05-04T09:34:18Z
dc.date.available 2015-05-04T09:34:18Z
dc.date.issued 2011ca
dc.description.abstract This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA. Gene polymorphisms related to reduced serotonin function, poor competency of executive control and memory consolidation systems, and high enzymatic activity linked to bioactivation of MDMA to neurotoxic metabolites may contribute to explain variations in the cognitive impact of MDMA across regular users of this drug. Sixty ecstasy polydrug users, 110 cannabis users and 93 non-drug users were assessed using cognitive measures of Verbal Memory (California Verbal Learning Test, CVLT), Visual Memory (Rey-Osterrieth Complex Figure Test, ROCFT), Semantic Fluency, and Perceptual Attention (Symbol Digit Modalities Test, SDMT). Participants were also genotyped for polymorphisms within the 5HTT, 5HTR2A, COMT, CYP2D6, BDNF, and GRIN2B genes using polymerase chain reaction and TaqMan polymerase assays. Lifetime cumulative MDMA use was significantly associated with poorer performance on visuospatial memory and perceptual attention. Heavy MDMA users (>100 tablets lifetime use) interacted with candidate gene polymorphisms in explaining individual differences in cognitive performance between MDMA users and controls. MDMA users carrying COMT val/val and SERT s/s had poorer performance than paired controls on visuospatial attention and memory, and MDMA users with CYP2D6 ultra-rapid metabolizers performed worse than controls on semantic fluency. Both MDMA lifetime use and gene-related individual differences influence cognitive dysfunction in ecstasyen
dc.description.sponsorship This study was supported by grants from the National Institutes of Health (NIH) grant no. 1 R01 DA017987, Grant 2005SGR00032, Fondo de Investigaciones Sanitarias (FIS-00/00777), Plan Nacional Sobre Drogas (INT/2012/2002) Spain, Plan Nacional Sobre Drogas: PNSD 2006/101(2007–2009) Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripten
dc.format.mimetype application/pdfca
dc.identifier.citation Cuyas E, Verdejo-Garcia A, Fagundo AB, Khymenets O, Rodriguez J, Cuenca A et al. The influence of genetic and environmental factors among MDMA users in cognitive performance. PLoS ONE. 2011;6(11):e27206. DOI: 10.1371/journal.pone.0027206ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0027206
dc.identifier.issn 1932-6203ca
dc.identifier.uri http://hdl.handle.net/10230/23514
dc.language.iso engca
dc.publisher Public Library of Science (PLoS)ca
dc.relation.ispartof PLoS ONE. 2011;6(11):e27206
dc.rights © 2011 Cuyàs et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Drogues -- Efectes secundarisca
dc.subject.other Memòria de curt termeca
dc.subject.other Polimorfisme genèticca
dc.title The influence of genetic and environmental factors among MDMA users in cognitive performanceen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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